1.Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases Acta Pharmaceutica Sinica BAvailable online 25 September 2022... Haowen
well as its effects on cardiac injury. Then, we discuss the relationship between the GSH system and ferroptosis in myocardial injury. Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may ...
allergic asthma mouse model, ginsenoside prodiol metabolite compound K (CK) can lower Th2 cytokines and IgE production, block mast cell activation and goblet cell proliferation, reduce airway hyperresponsiveness and inflammatory response, reduce ROS and MDA content, and upregulate SLC7A11 and GPX4. ...
48]. Phase separation of the type I subunit of protein kinase A (PKA RIα) mediates the homeostasis of intracellular 3’,5’-cyclic adenosine monophosphate (cAMP) and activation of the G protein coupled receptors; PKA RIα LLPS defect promotes cell growth and transformation...
type [15,16], which makes them very sensitive to oxidative stress damage. At the same time, the activity of antioxidant enzymes (SOD, GPX, GR) in cardiomyocytes is weaker than that in other organs [17], further aggravating the susceptibility to this injury. Therefore, targeted activation of...
While comprehensive reviews have been published recently [40], we will highlight recent dis- coveries that advanced the field with a particular focus on the role of LLPS in regulating nuclear chromosome organization and transcription. LLPS can promote the activation of the adaptive T-cell ...
These mechanisms include the activation of inflammatory mediators, alterations in renal hemodynamics, oxidative stress, and imbalances in glucose and lipid metabolism [Citation47]. Given the complexity of these processes, it is necessary to use network pharmacology methods to comprehensively analyze the ...
Cystathionine β-synthase (CBS) is responsible for the first enzymatic reaction in the transsulfuration pathway of sulfur amino acids. The molecular function and mechanism of CBS as well as that of transsulfuration pathway remain ill-defined in cell prol
The antiangiogenic activity of plumbagin has been facilitated by the RAS signaling pathway-mediated activation of vascular endothelial growth factor receptor-2 (Lai et al., 2012). Plumbagin dose-dependently inhibited oesophagal squamous cell carcinoma cell line, lower Polo-like kinase 1 and phosphor...
Corrigendum to “Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection” [Pharmacol. Res. 177 (2022) 106112] Xin Zhang, Xiuling Lin, Hui Luo, Yuanxing Zhi, ... Pingzheng Zhou ...