European Journal of Medicinal ChemistryKhan MSY, Mymoona A.Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen [J]. European Journal of Medicinal Chemistry, 2005,40(4): 371.Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ...
and Forchielli, E: Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs. Biochemical and Biophysical Research Communications 46: 552–559 (1972). Article PubMed CAS Google Scholar Traslosheros, J.C....
E. et al. Caveolin-1 regulates genomic action of the glucocorticoid receptor in neural stem cells. Mol. Cell. Biol 34, 2611–2623 (2014). Article Google Scholar Le Saux, C. J. et al. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute ...
Molecular mechanism of action and pharmacokinetic properties of methotrexate Article 15 May 2020 Voriconazole injection may induce delayed methotrexate excretion: a case report and experimental study Article Open access 26 March 2022 Adverse effects induced by diclofenac, ibuprofen, and paracetamol toxi...
With effervescent tablets, drug absorption and onset of action are more rapid than with conventional tablets. However, there is no direct correlation between serum concentrations of paracetamol and its analgesic or antipyretic effect. Paracetamol is the non-opiate analgesic of choice in elderly persons...
(n=5) belonging to the endorphin class. It is known to be involved in the basic mechanisms of analgesia. It produces a transient analgesic effect when administered parenterally, but no effect has been observed when given orally. Its mechanism of action is believed to involve binding to opioid...
Mice were kept on heating plates until full consciousness was retrieved and received 0.1 mg of enrofloxacin and 2 mg of ibuprofen per millilitre of drinking water for 1 week. Mice were allowed to recover from surgery for at least 2 weeks before wound clips were removed and analyses was...
(888)354). Hence,QSARbetweenelectrophiledetoxicationproperties and water/n-octanol logPvalues of numerousDTTs were checked (96IJP(129)295) and the regulation of phase 2enzyme inductionin the cancer protective action was investigated (94CAG177). As regards the oral toxicity ofDTTparent substance (...
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly t
Interactions of tricyclic antidepressants (TCAs) Tricyclic antidepressants (TCAs), introduced for the treatment of depression in the 1950s, are now rarely used due to numerous side effects [13]. The mechanism of action of these drugs is blocking the reuptake of neurotransmitters—norepinephrine and ...