Studies with rats reveal that CGS 13945 and CGS 13934 are orally effective inhibitors of ACE. Both inhibitors have a longer duration of action and are somewhat less effective than captopril. After oral administration, the bioavailability of the monoester CGS 13945 is greater than that of the ...
In the first part of the chapter the effects of pharmacological manipulations on peritoneal transport will be discussed. Increased understanding of peritoneal transport mechanisms may lead to the development of clinically useful methods to augment peritoneal transport efficiency. In this chapter only pharmac...
(2) the onset of action is delayed for approximately 4 to 6 weeks; and (3) the symptomatic effect is maintained after stopping the treatment for periods of 4 to 8 weeks.The methodology for evaluating the possible structure-modifying effect of drugs has dramatically improved during the past ...
2. The characteristics or properties of a drug, especially those that make it medically effective. phar′ma·co·log′ic (-kə-lŏj′ĭk), phar′ma·co·log′i·cal (-ĭ-kəl) adj. phar′ma·co·log′i·cal·ly adv. phar′ma·col′o·gist n. American Heritage® Dictiona...
Angiotensin receptor blockers (ARBs) which inhibit the action of ACE, an isoform of ACE2, are known to increase the expression of ACE2 [139] (Fig.1; Table2). The patients with diabetes and cardiovascular diseases regularly take ACE inhibitors and ARBs. Hence, they remain under continuous ...
Besides, the tissue-specific action of alkaloids remains to be clarified. Moreover, the synergistic effect between alkaloids or alkaloids and other components in C. yanhusuo still requires investigation. Hopefully, this article lays a foundation and may provide new insights for future researches. ...
select article ACE inhibitors can reverse blood vessel damage Short communicationNo access ACE inhibitors can reverse blood vessel damage Pramod R. Saxena, Arie J. Man In't Veld Pages 239-241 select article Specificity in the recognition process between charged carbohydrates and proteins ...
decrease in blood pressure in patients receiving concomitant therapy with calcium antagonists, especially those receiving dihydropyrimidines. Patients receiving chronic therapy with other ACE inhibitors or alpha-1-adrenoceptor antagonists may develop unpredictable hypotension with the use of any type of ...
In accordant, the combined action of curzerene and various minor constituents contributes to the overall antioxidant activity of the oils, surpassing that of hydroethanolic extracts of S. olusatrum leaves traditionally consumed in Southern Italy [71]. Furthermore, while some compounds exhibit ...
Paton WDM (1957) The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol 12:119–127 CAS Google Scholar Paton WDM, Zar MA (1968) The origin of acetylcholine released from guinea-pig intestine and longitudi...