The pharmacokinetic profile was similar to that of another rapid-acting insulin analogue, insulin lispro, on the basis of published information for that agent. Pharmacodynamic studies show a smaller excursion of postprandial glucose with insulin aspart injected subcutaneously just before the meal compared...
Accelerated pharmacokinetics and glucodynamics of prandial insulins injected with recombinant human hyaluronidase. BACKGROUND: This phase 1 study investigated the pharmacokinetics (PK) and glucodynamics of insulin lispro (Humalog; Eli Lilly and Co., Indianapolis, IN) or... DE Vaughn,RC Yocum,DB Much...
Comparison of Pharmacokinetics and Pharmacodynamics of Inhaled Technosphere Insulin and Subcutaneous Insulin Lispro in the Treatment of Type 1 Diabetes Mel... This study was performed to satisfy a US Food and Drug Administration post-marketing requirement to compare the dose responses for TechnosphereInsul...
insulin lispropharmacokineticsAn 8-mm needle length is commonly used for insulin injections; however, recent recommendations suggest shorter needles may help patients avoid intramuscular injections and reduce pain, while maintaining adequate glucose control. The goal of these analyses was to compare the ...
The risk of hypoglycemia is the main obstacle faced by efforts to achieve optimal glycemic control. The Lispro insulin analog is a recently developed compound whose faster kinetics as compared to soluble insulin ensure an effect that is closer to the physiologic postprandial profile. When injected ...
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin insulin analog Glargin, NPH insulin, and ultralente human insulin and continuous subcutaneous insulin of insulin Lispro These clinical studies were designed to compare LYSPRO with human Regular insulin after subcutane...
The pharmacokinetics (PK) of the photosensitizer tetra( m-hydroxyphenyl)chlorin (mTHPC) was measured by optical fiber-based light-induced fluorescence spec... T Glanzmann,M Forrer,SA Blant,... 被引量: 0发表: 2000年 Pharmacokinetics and pharmacodynamics of insulin Lispro compared with regular insul...
KL Garrison,S Sahin,LZ Benet - 《Journal of Pharmaceutical Sciences》 被引量: 19发表: 2015年 Pharmacokinetics and pharmacodynamics of lispro-insulin in hemodialysis patients with diabetes mellitus. Differences in elimination half-life and volume of distribution were explained by flip-flop pharmacokinetic...
Injection site effects on the pharmacokinetics and glucodynamics of insulin lispro and regular insulin. Diabetes Care. 1996;19(12):1437–40. Article PubMed Google Scholar Lobo ED, Hansen RJ, Balthasar JP. Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci. 2004;93(11):2645–68. ...
Intramuscular injection of insulin lispro or soluble human insulin: pharmacokinetics and glucodynamics in Type 2 diabetes. Z. Milicevic, V. Profozic, J. Wyatt, S. Ristic†,, J. R. Woodworth‡,, M. Seger‡,, D. Kaliterna, P. Bates<. Diabetic Medicine . 2001...