34、后的最高浓度一次给药后的最高浓度 此时吸收和消除达平衡此时吸收和消除达平衡达峰时间达峰时间(Tmax)曲线下面积曲线下面积单位:单位:ng h/mL 反映药物体内总量反映药物体内总量Area under curve (AUC)(1)稳态血药浓度)稳态血药浓度 (Steady-state concentration) 目的:多次给药使血药浓度达有效范围目的:多次...
Cmax, Tmax and AUC in sheep, goats and deer given 0.2 mg/kg abamectin per os and then manipulate the dose rate for any variation to match that of sheep. The blood samples obtained from these animals were analysed by HPLC-Fluorescence detector using a validated method of analysis. Goats...
No significant differences between study populations were observed for peak plasma level (Cmax) or exposure (AUC). In healthy volunteers, a shift in time to Cmax(Tmax) was observed after a high‐fat meal, but there was no change in AUC. LTB4 production was reduced in the blood of both ...
The mean Cmax, tmax, and AUC(0?12)were (21.88±10.52) μg/ml, (1.20±0.95) h, and (52.546±13.215) μg·h/ml, respectively. The level of AUC(0?12) in the FK506 group was significantly higher than that in the CsA group. MPA appeared not to be affected by renal function. MPA...
Determination of Pharmacokinetic Parameters AUC, Cmax, and Tmax values for irinotecan, SN-38, and SN-38G were calculated using Phoenix WinNonlin 5.2 software. Pharmacokinetic Modeling A pharmacokinetic model was developed using Phoenix NLME software to simultaneously predict irinotecan and SN-38 ...
The PK parameters, such as T1/2, Vd, CL, AUC, Tmax, and Cmax showed no significant difference between day 1 and day 14, implying linear kinetics. The elimination half-life was 4.00- 4.58 h, suggesting UAL was quickly eliminated from blood [129]. However, no acute or surrogate PD ...
Pharmacokinetics including AUC, tmax, Cmax and half 鈥 life were estimated using WinNonLin. Cyclophosphamide concentrations in blood obtained after sampling through tail vein were close to those obtained after retro-orbital bleeding within the same animal. No significant differences in estimated ...
Cmax peak concentration, Cmin trough concentration, AUC area under the concentration–time curve, MIC minimum inhibitory concentration, GM test detection of galactomannan, G test detection of (1–3)-β-D-glucan, IFD invasive fungal disease Full size image 3.4 Toxicity No clear relationship between...
Prednisolone-21-acetate, when administered in oral suspension at a dose equivalent to 15 milligrams, demonstrates specific pharmacokinetic characteristics. It achieves a maximum concentration (Cmax) of 321.1 nanograms per hour, with a time to reach this peak (Tmax) of approximately 1 to 2 hours....
There was no statistical significance in maximum concentration (Cmax) or morning/night trough levels between patients with and without AR. In regard to the correlation between tacrolimus concentrations in each sampling time and AUC012, the morning trough concentrations were less predictable for daytime ...