Pharmacokinetic drug–drug interactions can be explained as the interaction between two or more different drug molecules after their coadministration or during their simultaneous systemic availability in a subject, at the absorption, distribution, metabolism, and elimination processes. Pharmacokinetic drug–...
Yee et al., Pharmacokinetic Drug Interactions with Cyclosporin (Part I) , Clinical Pharmacokinetics, 19(4):319 322, 1990.Yee GC, McGuire TR. Pharmacokinetic drug in- teractions with cyclosporin (Part I). Clin Pharmacokinet. 1990;19:319-332....
drug‐drug interactionethinyl estradioloral contraceptivespharmacodynamicspharmacokineticsprogestinstudy designOral contraceptives (OCs) are the most widely used form of birth control among women of childbearing potential. Knowledge of potential drug-drug interactions (DDIs) with OCs becomes imperative to ...
aAlthough it appears that a pharmacokinetic drug-drug interaction (DDI) was not demonstrated between docetaxel and plinabulin via apreliminary cross-study comparison, FDA will make the determination whether further evaluation is necessary after receiving the final study report. 虽然看起来约物动力学的药物...
Prediction of pharmacokinetic drug–drug interaction caused by changes in cytochrome P450 activity using in vivo information. Akihiro Hisaka,Yoshiyuki Ohno,Takehito Yamamoto,Hiroshi Suzuki. Pharmacology & Therapeutics . 2010Hisaka A, Ohno Y, Yamamoto T, and Suzuki H (2010) Prediction of pharmacokinetic...
However, administration of rifampicin in combination with antiretroviral therapy, particularly protease inhibitors, is difficult because of drug鈥揹rug interactions... J Mallolas,M Sarasa,M Nomdedeu,... - 《Hiv Medicine》 被引量: 80发表: 2010年 Evaluation of the drug interaction between rifabutin...
This study was devised to investigate if P-glycoprotein (P-gp) mediated the drug–drug interaction (DDI) between genistein and repaglinide. When genistein was added, the plasma concentrations of repaglinide in rats were increased. The maximum plasma concentration (Cmax) of repaglinide increased from...
During drug development, it is essential to gather information about the change of clinical exposure of a drug (object) due to the pharmacokinetic (PK) drug-drug interactions (DDIs) with another drug (precipitant). While many natural language processing
Olaparib is a PARP (poly-ADP-ribose polymerase) inhibitor used for maintenance therapy in BRCA-mutated cancers. Metformin is a first-choice drug used in th
As new classes of antimicrobial drugs have become available, and new uses found for older drugs, pharmacokinetic drug interactions with antimicrobials have become more common. Macrolides, fluoroquinolones, rifamycins, azoles and other agents can interact adversely with commonly used drugs, usually by alt...