Coevolution between bacteriophages (phages) and their bacterial hosts occurs through changes in resistance and counter-resistance mechanisms. To assess phage–host evolution in wild populations, we isolated 195strains and 243 vibriophages during a 5-month time series from an oyster farm and combined ...
Phage–host coevolution in natural populations. Nat. Microbiol. 7, 1075–1086 (2022). Article PubMed CAS Google Scholar Samson, J. E., Magadán, A. H., Sabri, M. & Moineau, S. Revenge of the phages: defeating bacterial defences. Nat. Rev. Microbiol. 11, 675–687 (2013). Article...
At this level, a panel of phages from PCL1 are used to perform the phage host-range determination on a collection of genome-sequenced target bacterial strains co-isolated from the same infective environment in a diverse set of relevant conditions. Essentially PCL2 provides a quick killing matrix...
The rise of multi-drug-resistant (MDR) bacteria has spurred renewed interest in the use of bacteriophages in therapy. However, mechanisms contributing to phage-mediated bacterial clearance in an animal host remain unclear. We investigated the effects of host immunity on the efficacy of phage therapy...
but also offers key insights into how bacterial populations and communities are structured across time and space. In this chapter, we provide, first, an overview of coevolutionary theory relevant to bacteria-phage interactions. Next, we summarize the findings of experimental coevolution studies, focu...
Phage–host coevolution in natural populations Article27 June 2022 Introduction Microbial organisms are pervasive across all natural environments, including the human body. Their adaptation and organization in communities may lead to disease1, drive host evolution2, and produce major changes in ecosystems...
The aim was to obtain a comprehensive picture of the coevolution dynamics in naturally evolving populations at relatively high time resolution. Coevolution was followed by monitoring changes over time in the CRISPR loci ofmetagenome-assembled genome, and reciprocal changes in the viral genome. Genome...
These phages can either integrate into the genomes of bacterial hosts or reproduce within, and then lyse their host cells. In both cases phages are able to shape the evolution and ecology of bacterial populations, often with important consequences for other interacting species or ecological and ...
However, knowledge about the diversity and coevolution of phages with their respective Rhizobium populations is lacking. Here, through the study of four phage-Rhizobium communities in Mexico and Argentina, we show that both phage and host diversity is spatially structured. Cross-infection experiments ...
Additionally, phage candidates should exhibit the broadest host range possible against the target bacterium. When necessary, the host range might be broadened by serial passages on different bacterial strains, thus allowing adaptation of the bacteriophages by coevolution with their host11. Also, there ...