小菜蛾肽聚糖识别蛋白酚氧化酶细胞表达肽聚糖识别蛋白(Peptidoglycan Recognition Proteins,PGRPs)是可以识别肽聚糖和含肽聚糖的细菌的一类模式识别受体,在介导酚氧化酶级联反应中起着重要的作用.本研究以实验室克隆的小菜蛾Px PGRP-SA(Gen Bank No.EU399240)为基础,RT-PCR克隆了其开放阅读框(ORF),在原核细胞中获得...
We report here the crystal structure of PGRP-SA at 1.56 Å resolution, which represents the first example of a “recognition” PGRP. Comparison with the catalytic Drosophila PGRP-LB reveals an overall structure conservation with an L-shaped hydrophilic groove that is likely the PGN carbohydrate ...
刘俊熠目前担任湖南研习文化发展有限公司法定代表人,同时担任湖南研习文化发展有限公司执行董事、总经理;二、刘俊熠投资情况:刘俊熠目前是湖南研习文化发展有限公司直接控股股东,持股比例为100%;目前刘俊熠投资湖南研习文化发展有限公司最终收益股份为100%;三、刘俊熠的商业合作伙伴:基于公开数据展示,刘俊熠与杨新冬为商业...
蛋白与预期大小相符.PGRP-SA在家蝇3龄幼虫血淋巴,脂肪体,前肠,中肠,气管,马氏管都有表达,血淋巴组织中表达量最高,后肠无表达,由此说明PGRP-SA基因的表达具有一定的组织性.PGRP-SA重组蛋白能与金黄色葡萄球菌和大肠杆菌结合,与白色念珠菌不能结合.成功表达及纯化家蝇PGRP-SA蛋白,证实家蝇PGRP-SA能与金黄色葡萄...
PGRP-SA is fundamental for controlling bacterial numbers in flies infected with a S. aureus mutant that lacks WTA.Magda, L. AtilanoJames, YatesMarcus, GlittenbergSergio, R. FilipePetros, Ligoxygakis
Reiser J B,Teyton L,Wilson I A.Crystal Structure of the Drosophila Peptidoglycan Recognition Protein (PGRP)-SA at 1.56 ? Resolution. Journal of Molecular Biology . 2004Reiser J B,Teyton L,Wilson I A.Crystal Structure of the Drosophila Peptidoglycan Recognition Protein (PGRP)-SA at 1.56 ?
2006. Sensing of gram-positive bac- teria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO J. 25: 5005Ð 5014.Wang L, Weber AN, Atilano ML, Filipe SR, Gay NJ, Ligoxygakis P. Sensing of gram-positive bacteria in Drosophila: GNBP1 is needed to ...
The soluble PRRs GNBP1, PGRP-SA, and PGRP-SD are unlikely to function as opsonins. A-C.Nadine T. NehmeJessica QuintinJu Hyun ChoJanice LeeMarieCéline LafargeChristine KocksDominique Ferrandon