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To assess vaccine efficacy, the unvaccinated group was compared with the vaccine group for time to first detectable parasitaemia after the final challenge using a log-rank test, and the presence or absence of parasitaemia using a two-tailed Barnard’s test. In the pilot PfSPZ-CVac(PYR + CQ)...
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Briefly, the histone proteins were propionylated to label unmodified and monomethylated lysines with a propionyl group (+56 Da), which will result in a trypsin digest cleaving only at arginine residues. This produces the same histone peptide sequences regardless of any post-translational ...
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