GujaratPatelGujaratSaumyaGujaratK.GujaratJhaGujaratPrakashGujaratTaylor & Francis GroupJournal of Biomolecular Structure and DynamicsStructural insights into the theoretical model of Plasmodium falciparum NADH dehydrogenase and its interaction with artemisinin and derivatives:towards global health therapeutics. Kumar...
Notably, samples from Sudan depicted a distinct haplotype and population structure compared to other countries.#These findings contribute significantly to our understanding of the genetic structure and evolutionary trends ofPfmdr1, which can help to strengthen the current malaria control policies for ...
Chloroquine Tolerance in 3D7 Strain of P. falciparum was Associated with Change in Allelic Structure and not Pfcrt and Pfmdr1 Transporter Genes nor DNA MethylationMartin Maina WahomeJosphat Nyandieka NyatayaHosea Miima AkalaGeorge Odhiambo Awinda...
Their exact mechanism of antimalarial action is unknown but the structure鈥揳ctivity relationships for malarial parasite inhibition and immunosuppression differ markedly. The 3鈥 -keto derivative of cyclosporin D (valspodar) is particularly potent against the human malarial parasite Plasmodium falciparum in...
Sequences were aligned with ClustalW and analysed by Ali2D revealing a high level of secondary structure conservation. To validate a potential drug binding pocket we performed antimalarial docking simulations. Using aminoquinoline as probe drugs in PfMDR1 mutated parasites we evaluated the physiology ...