该品系代表了产生巨核细胞谱系限制特异性靶向突变体的有效工具。 Tiedt R , et al. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo.
C57BL6 wild-type (Jackson laboratories, Harbor, ME) mice were bred, maintained at The Saban Research Institute (TSRI) animal care facility, and handled in accordance with IACUC rules and regulations of the TSRI at Children’s Hospital Los Angeles. ...
/Ldlr ?/? mice. In a mouse model of tail injury, Pf4-ΔCre–mediated and Gp1ba-ΔCre–mediated deletions of Cox-1 were similarly efficient in suppressing platelet prostanoid biosynthesis. Experimental thrombogenesis and attendant blood loss were similar in both models. However, the impact on ...
Comparison of Pf4-Cre(neg);α2flox/flox mice (f/f), heterozygous Pf4-Cre(neg);α2+/flox mice (f/−) and α2-cKO mice (−/−).David, HabartYann, CheliDiane, J. NugentZaverio, M. RuggeriThomas, J. Kunicki