Inhibition of the CX3CL1-CX3CR1 axis suppresses the infiltration and secretion of CXCL16 by PF4 + macrophages, thereby reinvigorating cytotoxic CXCR6 + CD8 + T cells and enhancing sensitivity to anti-CD276 treatment. Further investigations demonstrate that inhibiting ITGB6 restores sensitivity to ...
Angiotensin II drives the production of tumor-promoting macrophages Immunity, 38 (2013), pp. 296-308 View PDFView articleView in ScopusGoogle Scholar De Palma and Naldini, 2002 M. De Palma, L. Naldini Transduction of a gene expression cassette using advanced generation lentiviral vectors Methods ...
To obtain monocytes/macrophages, PBMCs were isolated from 50 mL of blood by centrifugation over a Ficoll-Paque density gradient (GE Healthcare Biosciences) 45 minutes at 400g. Cells were removed from the upper band located at the interface between the plasma and resolving medium. Cells were the...
CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes. CXCL4 does not contain an ELR motif. However, many other functions have been observed for CXCL4. CXCL4 is involved in monocyte survivial and differentiation into macrophages, and it has anti-angiogenic activity. CXCL4 has been dem...
2. Association between VEGF expression in tumour-associated macrophages and elevated serum VEGF levels in primary colorectal cancer patients [J] . Francisco J. Gonzalez, Luis Vicioso, Martina Alvarez, Cancer Biomarkers . 2007,第6期 机译:原发性大肠癌患者肿瘤相关巨噬细胞中VEGF表达与血清VEGF水平升...
Running head: Reprogramming of neutrophils into macrophages We examined the effects of interleukin (IL)-13 and IL-4 on growth of hematopoietic progenitors from 5-fluorouracil (5-FU)-treated mice, using an in vitro c... H Araki,N Katayama,Y Yamashita,... 被引量: 0发表: 0年 加载更多研究...
[1] Minoru Takaoka et al., Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis. Nature (2024) Doi: https://doi.org/10.1038/s41586-024-07993-x [2] Jean-Rémi Lavillegrand et al., Alternating high-fat diet enhances atherosclerosis by neutrophil reprogramming. Nature...
Further, the knowledge that PF4 forms antigenic complexes with GAGs on monocyte/macrophages20,21 suggests that similar events are likely to occur on dendritic cells within the immune compartment, thus “priming” the immune system in susceptible individuals. We suspect that the absence of vascular ...