The number of embryos per genotype and the percentage of embryos per group showing axonal defects is summarized in H. Scale bar 50 μm Full size image As shown in Fig. 4, ubiquitous downregulation of Eip63E resulted in axon defects and lethality similar to those observed with the germline-...
d Weight change at day 4 pi in percentage, normalized to the body weight at the day of infection. Bars represent means ± SD. Data were analyzed with the Mann–Whitney U test (two-sided). **P = 0.0031, ***P = 0.0003. e Cumulative severity score from H&E stained ...
At week 21 of differentiation, the 3D retinae were flattened down on multi-electrode arrays (MEAs) with the presumed ganglion cell layer facing down on the electrodes, in order to record action potentials generated by these cells. Measuring activity in retinal ganglion cells (RGCs) reflects the ...