最终纳入PD 27例[男23例,女4例,平均年龄(59.5±12.1)岁],对其采用帕金森病统一评分量表第Ⅲ部分(unified-Parkinson's disease rating scale,UPDRS Ⅲ)和帕金森病病情分级表(Hoehn-Yahr,H-Y)[8]进行临床评分。同时招募健康对照24例...
MRI18F-FDG PETTo investigate the diagnostic value of brain magnetic resonance image (MRI) and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty-five patients with MSA (23 MSA-P and 12...
帕金森病(Parkinson's disease,PD)是一种进行性神经退行性疾病[1],其特点为与路易体相关的PD经典运动特征和黑质多巴胺能神经元丧失,如静息性震颤、强直、运动障碍和姿势不稳定[2]。了解PD疾病进展速度,特别是在早期阶段,对于评估潜在神...
[19]Gu S, Ye Q, Yuan C. Metabolic pattern analysis of 18F-FDG PET as a marker for Parkinson’s disease: a systematic review and meta-analysis[J]. Rev Neurosci, 2019, 30(7): 743-756. DOI: 10.1515/revneuro-2018-0061. [20]Mure H, Hirano S, Tang CC, et al. Parkinson’s diseas...
doi:10.1016/J.NICL.2018.11.004Franziska AlbrechtTommaso BallariniJane NeumannMatthias L. SchroeterElsevierNeuroImage: Clinical
doi:10.1016/j.jns.2017.08.098PicciniP.Journal of the Neurological Sciences
Dopamine depletion and microstructural degradation underlie the neurodegenerative processes in Parkinson's disease (PD). To explore early alterations and underlying associations of dopamine and microstructure in PD patients utilizing the hybrid positron emission tomography (PET)-magnetic resonance imaging (MRI...
Parkinson's disease (PD) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional NM loss and iron accumulation within specific areas of SN relate to nigro-striatal ...
PARKINSON'S diseaseMACHINE learningMAGNETIC resonance imagingObjectives: To construct a machine learning model for differentiating Parkinson's disease (PD) and multiple system atrophy (MSA) by using multimodal PET/MRI radiomics and clinical characteristics. Methods: One hundred and nineteen patients (81 ...
In a normal brain the spatial distribution of resting cerebral blood flow and cerebral metabolic rate of glucose are closely related. A relatively new MR technique, Arterial Spin Labeling (ASL), is used to measure brain perfusion. It produces perfusion weighted images in aLK Teune...