radiotracer dosage and uptake time), scanner vendors, reconstruction algorithms (e.g. matching of resolution and iterative reconstruction convergence) and data analysis [157,158]. The inferior spatial resolution and unsatisfactory
The Centiloid (CL) scaling was developed to provide standardized amyloid-PET data on a universal unbounded 0 (mean gray matter signal in healthy young adults) to 100 (mean signal in patients with typical AD) scale, regardless of the radiotracer used [13]. To our knowledge, the CL scale ...
When considering patient workflow, one must consider where patients will be injected with the radiotracer and when screening for MRI safety occurs. Additionally, PET/MRI facilities should be designed with both MRI and radiation safeties in mind. Below we discuss the specific safety concerns ...
The PET scan is used in place of, but not in addition to, a single photon emission computed tomography (SPECT), in persons who meet medical necessity criteria for a cardiac SPECT (seeCPB 0376 Single Photon Emission Computed Tomography (SPECT));or For use in assessment of coronary artery dis...
Preparation FDG is normally prepared in a centralised PET radio- pharmacy by phase transfer catalysed nucleophilic sub- stitution of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethane- – Chemical purity; (using HPLC with ultraviolet or conductivity detection), to ensure the absence of any compounds ...
CNS MPO and CNS PET MPO also predicted that reducing the lipophilicity would increase the likelihood of a successful CNS drug/PET radiotracer, respectively. However, two radiotracers were explored with lower lipophilicities, [18F]OXD-2188 and [18F]OXD-2189, and neither showed improved brain ...
(FDG-PET) for detection of lymph node metastases from prostate cancer is notoriously low.2Several other radio pharm aceuticals have been developed to characterize aspects of tumor metabolism apart from glycolysis, offering an alternative to18F-FDG i...
PET radiotracer synthesis [11C]PBR28 was synthesized by the Martinos Center Radiotracer Production Lab for immediate use in MR–PET imaging. In short, the desmethyl precursor (1 mg in 100 µl of N,N-dimethylformamide) is loaded into a 5-ml stainless-steel loop for reaction with 11...
[18], PET identified a smaller metabolically active area than radiographically suspected in 23% of poorly demarcated lesions. Munley et al. [25] showed that pre-radiotherapy PET images would have influenced target volume localization in 15% of the patients. Kiffer et al. reported that the PT...
FDG PET during radiochemotherapy is predictive of outcome at 1 year in non-small-cell lung cancer patients: a prospective multicentre study (RTEP2). Eur J Nucl Med Mol Imaging 2014; https://doi.org/10.1007/s00259-014-2687-9 Kong FM, Ten Haken RK, Schipper M, Frey KA, Hayman J, ...