PregnancyAdultPregnant WomenGreat BritainFemaleObjective To examine the safety of pertussis vaccination in pregnancy.Design Observational cohort study.Setting The UK Clinical Practice Research Datalink.Participants 20074 pregnant women with a median age of 30 who received the pertussis vaccine and a matched...
A slightly higher incidence of chorioamnionitis was observed in the group of mothers vac- cinated during pregnancy compared to the nonvaccinated cohort (6.1% vs 5.5%), but this difference was not statistically significant. Finally, the safety report from the UK maternal Tdap vaccination program ...
Pertussis vaccination in pregnancy may protect infants through passive and active transfer of maternal antibodies that protect the infant until the primary immunization series. Studies show vaccinating pregnant women with acellular pertussis vaccine is safe for mother and infant, immunogenic with efficient ...
Vaccination against pertussis has reduced the disease burden dramatically, but the most severe cases and almost all fatalities occur in infants too young to be vaccinated. Recent epidemiologic evidence suggests that targeted vaccination of mothers during pregnancy can reduce pertussis incidence in their in...
such children are susceptible to pertussis beforeactive immunitycan be induced by DTaP.Vaccinationis recommended in pregnancy as a way of reducing infant pertussis through both decreasing the risk for transmission of disease to the infant from the mother and through transfer ofmaternal antibodiesagainst...
Table 2Current pertussis vaccination schedules in Western countries (modified from[7],[37], and[38]) Full size table Possible implementation strategies to be adopted in Western countries Vaccination of women during pregnancy Several countries, including US and UK, currently recommend Tdpa administration...
The WHO recommends vaccination of all children against pertussis. However, newborn infants remain vulnerable to infection. Pertussis vaccination during pre
P. Effectiveness of vaccination during pregnancy to prevent infant pertussis. Pediatrics 139, e20164091 (2017). Article PubMed Google Scholar Skoff, T. H. et al. Impact of the US maternal tetanus, diphtheria, and acellular pertussis vaccination program on preventing pertussis in infants <2 ...
We agree that one explanation of these results may be the potential protective effect that influenza vaccination during pregnancy has on pre-term birth. This protective effect of influenza vaccines against a range of adverse birth outcomes has been noted in other studies. An alternative explanation,...
Vaccination during pregnancy is a primary prevention strategy to reduce the risk of pertussis infection in unvaccinated and partly vaccinated infants [9,156]. Pregnant women should be targeted because as well as reducing the risk of mother-to-infant infection, maternal Tdap vaccination is reported to...