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Until recently the application of artificial intelligence (AI) in precision oncology was confined to activities in drug development and had limited impact on the personalisation of therapy. Now, a number of approaches have been proposed for the personali
This review examines the computational methods and modeling necessary to design virtual patients. Especially, the models and data required are reviewed, and the different levels of validation possible for the resulting virtual patients are discussed. It also notes how virtual trials could be used to ...
Versions Notes Abstract Application of new methodologies at Spanish universities is essential to improve the teaching–learning process, although their implementation for the initial training of students is not common. The aim of this study was to use the flipped classroom (FC) methodology in the spo...
Review ReportsVersions Notes Abstract Long-term reductions in the quantity of food consumed, and a shift in intake away from energy dense foods have both been implicated in the potent bariatric effects of Roux-en-Y gastric bypass (RYGB) surgery. We hypothesised that relative to pre-operative ass...
In a post hoc exploratory sub-study of the IMpassion130 trial (first-line Atezolizumab plus Nab Paclitaxel for metastatic TNBC), Rugo, et al., investigated analytical concordance and clinical utility among different assays, to evaluate PD-L1 (the VENTANA SP142, VENTANA SP263 and Dako 22C3) ...
A texture analyser TA HD plus (Stable Micro Systems, Surrey, UK) was used to investigate the mechanical properties of the placebo and the drug loaded filaments. Five specimens were tested for each filament formulation. The gauge lengths and the total lengths were set to 8 cm and 12 cm, res...
Sections were counterstained with haematoxylin (Novolink, Leica Biosystems Newcastle Ltd., Newcastle Upon Tyne, UK). Staining patterns and intensities were assessed by two of the three experts in histology (V.V., H.B. and R.Gy.) and cross-referenced by an expert pathologist (E.T.). Inter...
Versions Notes Abstract Bronchiectasis is a heterogenous disease with multiple aetiologies resulting in inflammation and dilatation of the airways with associated mucus production and chronic respiratory infection. The condition is being recognised ever more frequently as the availability of computed tomography...