The function of PPs is mostly mediated by a group of specific receptors, known as peroxisome proliferator-activated receptors (PPARs), which belong to the nuclear receptor superfamily. Upon ligand binding, PPARs dimerize with retinoid receptors, translocate to the nucleus, recognize specific PP-...
Theperoxisomeis a single membrane organelle present in virtually all eukaryotic cells. While the enzymatic composition and metabolic function of peroxisomes can vary from cell to cell, tissue to tissue, and organism to organism, there are a few common themes to peroxisomal metabolism inmammalian cells...
The hydroxyl function can be activated by conversion to a halide or tosylate prior to reaction with different nucleophiles like ammonia, amines, thiols, etc. The Mitsunobu reaction is also useful for the conversion of a hydroxylgroup into other functional groups. (Mitsunobu, O, Synthesis, 1981, ...
Expression of Pex25p only, led to recovery of peroxisomal function in these cells (Fig. 1B). Furthermore, in favor of the notion that Pex30p and Pex25p act on the same pathway, mutant cells lacking both Pex25p and Pex30p could use oleate better than cells lacking only Pex25p. Pex...
‘Remove Column’ function. Furthermore, the extracted raw data were pre-processed with a low variance filter in order to reduce the dimensionality of the dataset and filter out descriptors that have least impact on the target variable. An upper bound of 20% was chosen; thus, descriptors ...