Despite great advances in the identification and characterization of essential components and molecular mechanisms associated with the biogenesis and function of peroxisomes, our understanding of how peroxisomes are incorporated into metabolic pathways and cellular communication networks is just beginning to ...
Interestingly, in mammalian cells, co-localization with the mammalian peroxisomal marker SelectFXTM was not observed. These data suggest fundamental differences in peroxisome composition, development or function between plant and animal cells.doi:10.1111/j.1365-313X.2010.04153.x...
Overexpression of these proteins in combination with laser-scanning fluorescence microscopy co-localized Rab6, Rab8, Rab10, Rab14, and Rab18 with peroxisomal structures. By analogy to the role these proteins play in other organelle dynamics, we may envisage what the function of these proteins may...
K.P.Baran, inEncyclopedia of Toxicology (Third Edition), 2014 Abstract -activated receptors (PPARs) are a group of. They function as transcription factors and act to regulate gene expression, thus impacting cellular development and diverse metabolic functions including hydrogen peroxide–based respirati...
Di Benedetto R, Denti MA, Salvati S, Sanchez M, Attorri L, David G, Di Biase A (2008) RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function. Neurochem Int 52:1106–1113 ...
(MAPL) containing a RING finger domain. MAPL appeared to have a regulatory function in controlling mitochondrial morphology. Excitingly, MAPL was also incorporated within unique, vesicular structures, which emanated from the sides of mitochondria. These new mitochondrial-derived vesicles (MDVs) (70–...
We have now studied fibroblasts from seven patients representing five complementation groups of the syndrome (defined by complementation for peroxisome enzyme function). We find that empty peroxisome ghosts are present in all seven cell samples. Three patients, representing three complementation groups, ...
A small family of glutaredoxins exists in S. cerevisiae[13]. However, it remains unclear whether any of them reside within the peroxisome lumen. It has been shown recently that S. cerevisiae Gto1, one of the three omega-class glutathione transferases whose function is related to the dithiol...
Various cell types of the immune system are affected in their function after PPARγ activation. In dendritic cells (DC), for instance, it prevents pro-inflammatory cytokine production and maturation, which can impede DC priming of CD4 T cells [6], and it affects DC migration and adhesion [7...
These studies also demonstrate a novel, alternative mechanism for carcinogenesis related to the accumulation of hepatic linoleic acid in Ppara-null and PPARA-humanized mice, an effect related to the loss of the PPARα regulation of lipid metabolism in hepatocytes. While no loss-of-function mutations...