a highly potent hypolipemic drug, show only very weak peroxisome proliferation in guinea pigs liver and human hepatoblastoma cell line (HepG2), in contrast to treated rats liver in vivo and to rat hepatoma cell line (Fao).Supported by GIS Toxicologie Cellulaire de Dijon and Conseil Regional ...
First, we review emerging evidence that changes in peroxisome activity can be linked to the epigenetic regulation of cell function. Next, we outline how defects in peroxisome biogenesis may directly impact cellular pathways involved in the development of disease. In addition, we discuss how changes ...
Here, we investigated the role of PPARgamma in dendritic cells (DC), the most potent antigen-presenting cells. We showed that PPARgamma is highly expressed in immature human monocyte-derived DC (MDDC) and that it may affect the immunostimulatory function of MDDC stimulated with lipopolysaccharide...
Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer The gamma isoform of the peroxisome proliferator-activated receptor, PPAR gamma, regulates adipocyte differentiation and has recently been shown to be expr... P Sarraf,E Mueller,WM Smith,... - 《Molecular Cell》 被引量: ...
One of the most rapidly developing areas of organelle biology, which has a major involvement in biochemical pharmacology, is the research into the peroxisomal function. There is a large group of compounds that are capable of inducing liver enlargement, proliferation of peroxisomal structures, and indu...
Dynamics of peroxisome assembly and function Recent studies in human cells and in the yeast Yarrowia lipolytica have shown that peroxisomes consist of numerous structurally distinct subcompartments th... VI Titorenko,RA Rachubinski - 《Trends in Cell Biology》 被引量: 283发表: 2001年 PAY4, a Ge...
Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor γ Function in Adipocytes and Macrophages The nuclear receptor peroxisome proliferator activator receptor γ (PPARγ) is the target of antidiabetic thiazolidinedione drugs, which improve insulin re... MI Lefterova,DJ Steger,D Zhuo,....
b, Timelapse following mCherry-SKL foci formation in Pex13 WT cells (black arrow) and c, Pex13 S8 cells (orange and blue arrows). Scale bar 5 µm. d,e, mCherry-SKL foci fluorescence intensity of the cells imaged in panels b and c, respectively, plotted as a function of time ...
Overexpression of these proteins in combination with laser-scanning fluorescence microscopy co-localized Rab6, Rab8, Rab10, Rab14, and Rab18 with peroxisomal structures. By analogy to the role these proteins play in other organelle dynamics, we may envisage what the function of these proteins may...
Lipid homeostasis is controlled by the peroxisome proliferator-activated receptors (PPARα, -β/δ, and -γ) that function as fatty acid-dependent DNA-binding proteins that regulate lipid metabolism. In vitro and in vivo genetic and ph... U Dressel,TL Allen,JB Pippal,... - 《Molecular End...