Objective To study the genotype distribution of peroxisome proliferators activated receptors gamma(PPAR(?))C161→T gene in school children and its possible association with overweight/obese and serum glucose,lipidlevels.Method A total of 1173 primary school students aged 7 to 12 in a district of ...
School of Life Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea Na Yeon Park & Dong-Hyung Cho Corresponding author Correspondence toDong-Hyung Cho. Ethics declarations Conflict of interest The authors declare that they have no conflict of interest. ...
The data obtained contribute to our understanding of the role of GJIC inhibition in the perturbation of cell survival and proliferation caused by nongenotoxic hepatocarcinogens.doi:10.1007/s002040050524Fiona J. ElcockSchool of Biochemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK,...
Gout is the most common arthritic disease in human but was long neglected and therapeutic options are not satisfying. However, with the recent approval of the urate transporter inhibitor lesinurad, gout treatment has experienced a major innovation. Here
Notably, none of the PTS2 candidates located to peroxisomes. Conclusion In a few cases the PTS may oscillate from "silent" to "functional" depending on its surface accessibility indicating the potential for context-dependent conditional subcellular sorting. Overall, PTS2-targeting predictions are ...
1 Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea 2 Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34113, Korea...
After 4 weeks of liquid diet feeding, the animals were sacrificed at 11 a.m., at which time blood and liver tissue were collected. The studies were approved by the Indiana University School of Medicine Animal Care and Use Committee and the Veterans Affairs Animal Use Subcommittee. Assays from...
We found that a number of genes regulated by HS were dependent on PPARα for regulation. Furthermore, we showed that PPARα-null mice were more sensitive to the transcriptional effects of HS and exhibited a remarkably different transcriptional response compared to wild-type mice. Our findings ...
To over-express PPARγ-1 in VSMCs, cells were transduced with the recombinant adenovirus at titers of 100 MOI for 24 hours. Wild type PPARγ-1 adenovirus (Ad-wt-PPARγ) and mutation PPARγ-1 adenovirus were kind gifts from Dr. Qinglin Yang (Morehouse School of Medicine, Atlanta, USA)...
To evaluate the expression of PPARs in INS+ cell differentiation, we first compared their expressions in mouse embryonic pancreas in vivo (Figure 1a). PPARβ/δ displayed a robust increase from embryonic day E12 to E18 of gestation, and remained almost the same level to newborn pancreas. ...