JNK 訊息傳遞路徑PERK訊息傳遞路徑 platinum-resistant epithelial ovarian cancerapoptosisnilotinibevodiamineJNK signaling pathwayEpithelial ovarian cancer is the most lethal gynecologic malignancy. One reason for its poor prognosis is the difficulty in early diagnosis, while the other reason is the development ...
. Recently we have characterized p40 and p49 bands as JNK1–1 and JNK1–2 isoforms[39]. Initially, we thought that pJNK was the p40 isoform but, as we will see in next sections, pJNK has a molecular weight of 42 kDa. The phosphorylation of JNK was well correlated with pERK2 levels...
0.907.P=0.007).TheSNPrs2076431inJNKgenewasassociatedwithfastingplasmaglucoselevels(P=0.006)and waist.hipratios(P=0.019).TheSNPrs2239815in. )(BP7genewasassociatedwith2-hourplasmaglucoseIevelsaf【er75 goralglucoseload(P=0.0481intheobservedpopulation. ConclusionCommonvariantsatPERKandBIPIocicontributed JNK...
Similarly, gcn2 −/− MEFs expressing augmented levels of P-JNK, JNK, P-PERK, PERK and lower levels of P-AKT and P-FOXO3 also had lower clonogenicity and were more sensitive to epirubicin and PERK-inhibition. In addition, JNK1/2 deletion in MEFs resulted in reduced levels of GCN2,...
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In cultured myotubes, inhibition of PERK and JNK signaling abrogated the lipids deposition and ameliorated insulin resistance, and inhibition of JNK signaling reversed the impaired elasticity of myotubes induced by lipotoxicity. Collectively, our data suggest that activation of PERK/JNK signaling is an ...
Evodiamine from Evodia rutaecarpa induces apoptosis via activation of JNK and PERK in human ovarian cancer cells[J] . Tze-Chien Chen,Chih-Chiang Chien,Ming-Shun Wu,Yen-Chou Chen.Phytomedicine . 2016 (1)Chen T C; Chien C C; Wu M S;.Evodiamine from Evodia rutaecarpa induces apoptosis via ...
JNKAKTPharmaceutical inhibitors of the endoplasmic reticulum (ER)-stress modulator PERK (eIF2AK3) have demonstrated anticancer activities in combination therapies, but their effectiveness as a single agent is limited, suggesting the existence of possible compensatory cellular responses. To explore the ...
[目的]观察天麻素对SNL模型大鼠脊髓背角内HDAC1-5,pERK,p-p38及pJNK的影响.[方法]选取健康雄性SD大鼠48只,随机数字表法分成正常组,假手术组,SNL组及天麻素组,每组12只.Von-Frey细丝测量大鼠足底痛行为,免疫荧光染色观察大鼠脊髓背角内HDAC1-5的表达位置,Western Blot法定量分析脊髓背角内HDAC1-5,pERK,pJNK及...