Neuropathy can also result from severe vasculitides, a group of disorders in which blood vessels are inflamed. When the blood vessels are inflamed or damaged, blood supply to the nerve can be affected, injuring
Neuropathydiabetesadultssleep disordersPURPOSE: (RLS) affects 8% of the population and is identified in 21% of individuals with (T2DM). Symptoms of RLS manifest as discomfort in the legs (e.g., numbness, tingling, electrical stimulations), usually occurring at night or at rest (sitting or ...
What is peripheral neuropathy (PN)? PN is a type of nerve damage that can develop when your peripheral nerves are damaged. Peripheral nerves are located outside of the brain and spinal cord. These nerves send information from your brain and spinal cord to the rest of your body. Damage to...
Typically, peripheral neuropathy begins in the toes, moves to the feet and then up the legs as it progresses; this can also occur in the fingers, spreading to the hands and arms. This distribution is referred to as a “stocking-glove pattern.”4 Autonomic symptoms such as postural hypotensio...
of other platinum compounds having an acute peripheral sensory and motor toxicity with initial symptoms of paresthesia or cold-related dysesthesia during or within hours after infusion that is unique to oxaliplatin, whereas a chronic peripheral sensory neuropathy can be caused by all platinum ...
Ischemic optic neuropathy In most eyes, theblood supplyto the posterior part of the optic nerve is by the peripheralvascular systemonly, with no separate axial blood supply (Fig. 1B). That makes the axial part of the optic nerve more susceptible to ischemic damage than the peripheral part. ...
Hv1 expression was markedly up-regulated in mice or rats under chronic inflammation induced by the hind paw injection of Complete Freund’s adjuvant (CFA) (Fig. 1a, b; Supplementary information, Fig. S1a–d). The up-regulation was also observed in mice under chronic neuropathy induced by ...
Keywords SCN10A · Sodium channel · NaV1.8 · Channelopathy · Sensory neuropathy Introduction The voltage-gated sodium (NaV) channel N aV1.8, encoded by SCN10A, is preferentially expressed in dorsal root gan- glion (DRG) and trigeminal ganglion neurons and is present in ...
Restless Legs SyndromeDopamineDopamine AgentsReceptors, Dopamine D3Models, BiologicalRestless legs syndrome (RLS) is increasingly recognized as a manifestation of various forms of peripheral neuropathy, and in particular in association with amyloidosis, uremia, diabetes, cryoglobulinemia, and Charcot-Marie-...
Pain assessment neuropathic pain diabetic peripheral neuropathy Brief Pain Inventory Introduction Painful diabetic peripheral neuropathy (DPN), the burning, tingling, prickly, and shooting pain in hands, feet, and legs that sometimes accompanies diabetes, is a significant complication, affecting 15% or mo...