Especially chemotherapy-induced peripheral neuropathy (CIPN) is a relevant side effect to treat/avoid, since CIPN may be a dose limiting side effect of chemotherapy. The invention also relates to kits and to cancer treatment of a subgroup of patients, which subgroup has been topically pretreated ...
Hair loss on the affected part Shiny skin Weakness Muscle atrophy (loss of muscle tissue) Diagnosis and testing A detailed medical history and physical examination can identify causes of neuropathy. Blood testing, measurement of glucose levels, anelectromyogram(EMG, an electrical test of muscle functi...
peripheral neuropathy Peripheral neuritis Neurology A functional defect of nerves outside the spinal cord, due to damage of peripheral nerves, axons or myelin sheath Clinical Numbness, weakness, burning pain–especially nocturnal, loss of reflexes; Sx depend on whether the 1º disorder affects sensor...
and responsiveness of thesesensory inputsand outputs are reduced and/or compromised. For example, if an individual has age-related visual deficits that are further compounded by unaddressed VI,peripheral neuropathysecondary to diabetes mellitus, and reduced vestibular end-organ function as a result of ...
Diabetic peripheral neuropathy (DPN) is length-dependent peripheral nerve damage arising as a complication of type 1 or type 2 diabetes in up to 50% of patients. DPN poses a substantial burden on patients, who can experience impaired gait and loss of balance, predisposing them to falls and fr...
especially in background noise. Sensorineural hearing loss is accompanied by loudness recruitment, which often coexists with hyperacusis, and so can lead to “over recruitment.” Auditory neuropathy, only identified a two decades ago, is expressed as an auditory temporal processing disorders and has ...
They are usually painful, but people with peripheral neuropathy (eg, due to diabetes or alcohol use disorder) may not feel them. Infection of ischemic ulcers (wet gangrene) occurs readily, causing rapidly progressive cellulitis. The level of arterial occlusion influences location of s...
Also, peripheral neuropathy is reported in MS patients. However, the involvement of the peripheral nervous system (PNS) in MS neuropathic pain remains elusive. This study investigated the contribution of ASICs and peripheral neuropathy in MS-induced neuropathic pain. Elicited pain levels were as high...
We suggest that oxaliplatin acts on IB4 (+)-nociceptors to induce oxidative stress-dependent acute peripheral sensory neuropathy. Perspective Many drugs used to treat cancer produce pain as their dose-limiting side effect. We used a model of this pain syndrome induced by oxaliplatin to demonstrate...
Unfortunately, these drugs also affect normal cells and structures of the body, causing various deleterious and sometimes even devastating side effects (e.g., anaemia, diarrhea, nausea, vomiting, infections, neurological changes, fatigue, hair loss, infertility, pain and peripheral neuropathy) [4],...