Perilipin protein Plin1 localizes at the surface of lipid droplets in adipocytes and regulates lipolytic activity, hydrolysis of triacylglycerides. Differential transmembrane signaling defines the phosphorylation state of Plin1; unphosphorylated Plin1 restricts access of the hydrolytic lipases to lipid ...
HCV infection or core protein expression alone in transfected Huh7.5 cells increased expression of sterol regulatory element binding protein 1c (SREBP-1c) ... Bose,Sandip,K.,... - 《Journal of Virology》 被引量: 41发表: 2014年 Inhibition of Adipocyte Differentiation and Adipogenesis by Supercri...
Because both Fsp27 and Plin1 are adipocyte-specific, we investigated whether they form a complex in adipocytes. When endogenous Fsp27 from differentiated 3T3-L1 adipocytes was immunoprecipitated, Plin1 but not ADRP was present in the precipitated protein complex; reciprocally, the Fsp27 protein was...
3A). Simultaneously, part of the CTSB positive area was merged with F4/80, suggesting that CTSB protein was localized to macrophages and adipocytes (Fig. 3A, arrow). In ND mice, the expression of Ctsb mRNA was significantly higher in the adipocyte enrichment fraction (AEF) than the ...
Perilipin1, a lipid droplet associated protein has an important role in the regulation of lipolysis and lipid storage in adipocytes. Perilipin1 is also expressed in foam cells of atheroma plaques and could therefore play a role in the accumulation of lipids in arterial wall and in the development...
Lipid droplets, a morphologic feature of adipocytic tumors, are strongly regulated by associated proteins of the perilipin/PAT (perilipin, adipophilin, and tail-interacting protein of 47 kD) family. So far, the use of perilipins as markers for differential diagnosis of soft tissue tumors has ...
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Alternative Names Lipid droplet associated protein; PERI; Perilipin-1; PerilipinA; LIN1 Immunogen A synthesized peptide deriv...
ADRP (adipocyte differentiation related protein) also known as ADFP, adipophilin, or perilipin-2, is a member of PAT family which is responsible for the transportation of lipids and the formation of lipid droplets. ADRP is localized on the surface of lipid droplets in a variety of tissues and...
ADRP (adipocyte differentiation related protein) also known as ADFP, adipophilin, or perilipin-2, is a member of PAT family which is responsible for the transportation of lipids and the formation of lipid droplets. ADRP is localized on the surface of lipid droplets in a variety of tissues and...
Our data demonstrated a novel role of Pik3r1, independent of its regulatory function of phosphoinositide 3-kinase, in mediating the metabolic action of glucocorticoids. Thus, the inhibition of Pik3r1 in adipocyte could alleviate lipid disorders caused by excess glucocorticoid exposure. 2017 by the ...