Processes that balance adipose energy storage and release are tightly regulated, with inhibitory and stimulatory hormones acting on cell surface receptors of responsive adipocytes. Perilipin protein Plin1 localizes at the surface of lipid droplets in adipocytes and regulates lipolytic activity, hydrolysis...
Perilipin-1 expression is restricted to β-adrenergic stimulatable cells, such as adipocytes and steroidogenic cells, and is essential for β-adrenergic stimulatablelipolysis. The protein governs the ATGL- and HSL-mediated breakdown of fat in WAT in multiple ways (see below).ATGL activityis regulat...
1 Scientific RepoRts | 6:20975 | DOI: 10.1038/srep20975www.nature.com/scientificreportsPerilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradationYu Takahashi 1,*,† , Akihiro Shinoda 1,*,† , Haruhiko Kamada 2,3 , Makoto Shimizu 1 , Jun Inoue 1 &...
In this report, we investigated the regulation of Plin2 expression and its function in differentiated adipocytes of mouse embryonic fibroblasts (MEFs). Plin2 mRNA levels increased during adipocyte differentiation whereas protein levels did not. Plin2 was degraded through the ubiquitin-proteasome pathway ...
Perilipin (Peri) expression appears to be limited to adipocytes and steroidogenic cells, in which intracellular neutral lipid hydrolysis is regulated by protein kinase A. We have isolated cDNA sets and overlapping genomic fragments of the murine Peri locus and mapped chromosomal location, transcription ...
All Perilipin-1/PLIN1 genes Perilipin-1/PLIN1 基因功能 The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocy...
Perilipin A is the most abundant form on the lipid droplets of adipocytes. The phosphorylation of perilipin by PKA, which is accompanied by the phosphorylation and translocation of hormone-sensitive lipase from the cytosol to the lipid droplets, promotes lipolysis. There is evidence for the presence...
(HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body. Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy ...
一种调控脂解的重要蛋白——围脂滴蛋白Perilipin 万方数据
For example, PLIN1 is the major PLIN that binds to mature LDs in adipocytes, while PLIN2 and PLIN5 reside on mature LDs in liver and muscle cells, respectively27. In contrast, PLIN3 displays near ubiquitous expression and binds to early LDs as they bud from the ER but is later ...