This protein, which we term perilipin, is found in differentiated cultured 3T3-L1 adipocytes, but not in their precursor 3T3-L1 fibroblasts. Immunocytochemical studies with specific antiserum shows that the perilipin is closely associated with the periphery of lipid storage droplets in cultured ...
In this report, we investigated the regulation of Plin2 expression and its function in differentiated adipocytes of mouse embryonic fibroblasts (MEFs). Plin2 mRNA levels increased during adipocyte differentiation whereas protein levels did not. Plin2 was degraded through the ubiquitin-proteasome pathway ...
Perilipin2 (Plin2), also known as adipose differentiation-related protein (ADRP), or adipophilin, is a member of the PAT family involved in lipid droplet (LD) formation in the liver and peripheral tissues. Although Plin2 was originally identified as a highly expressed gene in adipocytes, its ...
Adipocytes Perilipin-Mediated Lipid Droplet Formation Sterol Regulatory Element-Binding Protein-1 Processing roliferator-activated receptor γ (PPARγ) Triacylglyceride Accumulation Sterol regulatory element-binding protein-1 (SREBP-1) 引用走势 2014 被引量:12 0...
Earlier studies in brown fat of young rats showed that in conditions of FA mobilization, myelin-like lamellar structures with a regular pattern of alternating dark and light bands were primarily found in the extracellular space and near LDs of adipocytes61,62,63. The periodicity of the structures...
It is located on lipid droplets, and expressed only in adipocytes and steroidogenic cells [20]. Perilipin has a single-copy gene that gives rise to three isoforms (A, B, and C) as a result of alternative splicing [13]. Perilipin A is by far the most abundant isoform [5]. The gene ...
Perilipin A is the most abundant form on the lipid droplets of adipocytes. The phosphorylation of perilipin by PKA, which is accompanied by the phosphorylation and translocation of hormone-sensitive lipase from the cytosol to the lipid droplets, promotes lipolysis. There is evidence for the presence...
The most highly studied member of the family, perilipin, is the most abundant protein on the surfaces of adipocyte lipid droplets, and the major substrate for cAMP-dependent protein kinase [protein kinase A (PKA)] in lipolytically stimulated adipocytes. Perilipin serves important functions in the ...
一种调控脂解的重要蛋白——围脂滴蛋白Perilipin 万方数据
important role in lipid droplets function,and thus lipid droplets are considered as active organelles in cells.Current evidences support that perilipin,a member of PAT family proteins,wholly regulates the metabolism of triglyceride in adipocytes.Here we reviewed the functions of perilipin in adipocytes....