Studies of overall adiposity, assessed by body mass index (BMI), have mainly implicated genes that provide support for a role of the central nervous system (CNS) in obesity susceptibility1–6,10,19, whereas genetic loci associated with body fat distribution, assessed by waist-to-hip ratio (...
Large-scale meta-analyses of genome-wide association studies (GWAS) for adiposity traits and obesity risk have identified at least 160 loci that contribute to body weight and fat distribution in adults and children of diverse ancestry1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,...