Here we report the intracellular delivery of exogenous DNA localized to the mitochondria ofusing a combination of mitochondria-targeting peptide and cell-penetrating peptide. Low concentrations of peptides were sufficient to deliver DNA into the mitochondria and expression of imported DNA reached ...
One such example is Patisiran which is composed of siRNA formulated in lipid-based carriers. More recently, peptide-based vectors have been emerged as promising candidates for gene delivery owing to their versatility, ease of synthesis, biocompatibility, and low cytotoxicity [6,7,16,17]. There ...
Drug carriers shield drugs from enzymes and other degradative factors. The size, charge, and hydrophobicity of a drug dictate its clearance rate. If a drug is below the glomerular filtration cutoff of ~60 kDa or 6 nm diameter, it will be cleared rapidly from systemic circulation via ...
Using ligand-specific binding and uptake tech- niques which employ vitamin B12, biotin, folate, and lectins to name a few, as drug carriers was also demonstrated. A more detailed discussion on these topics is covered elsewhere (Park et al. 2011; Karsdal et al. 2011, 2015). A ...
NLC: nanostructured lipid carriers; LEU: leuprolide; HIP: hydrophobic ion pair; SLN: solid lipid nanoparticles. 2.3.2 Particle size It was shown that the permeation rate of self-emulsifying drug delivery systems across mucus was influenced by the size of the nanocarriers with an increased transport...
These peptide‐based assemblies with structural and functional versatility can serve as immunotherapeutic agents such as antigens, adjuvants, drug delivery carriers or immunomodulators. This article reviews the effects of supramolecular peptide assemblies on cancer immunotherapy and highlights the unique role...
The disadvantage of peptide-based carriers is the low immunogenicity of the formed conjugates. Thus high dose is required to stimulate desired immune response which might be a potential obstacle in development of peptide-carrier-based self-assembled nanostructure. Limited understanding of the interaction...
Peptide carriers present several advantages, in that they are modulatable, lack immunogenicity, are easy to produce and can incorporate a number of specific attributes required for efficient cargo delivery and for controlling their cellular behavior. Moreover, in addition to their usefulness in the la...
For example, hair coloring compositions may contain sequestrants, stabilizers, thickeners, buffers, carriers, surfactants, solvents, antioxidants, polymers, and conditioners. Skin Care Compositions In another embodiment, the peptide-based body surface coloring reagent is a component of a skin care ...
bases, such as emulsifying bases or water-soluble bases. Formulations suitable for vaginal administration can be presented as pessaries, tampons, creams, gels, pastes, foams, or spray formulas containing, in addition to the active ingredient, such carriers as are known in the art to be ...