体内溶解（若涉及相关研究）：若考虑将 LMW Peptide 用于体内实验，溶解时需要考虑其生物相容性和安全性。通常可将其溶解于生理盐水中，对于难溶性肽，可能需要添加一些生物相容性好的增溶剂，如吐温 - 80 ，但添加比例需严格控制，以避免对实验动物产生不良影响。同时，要确保溶解后的溶液无菌，防止微生物污染。保存...
LMW peptide（低分子量肽，化学编号为1818202-23-1）是一种具有广谱抗菌活性的肽，它能够对抗革兰氏阳性菌和革兰氏阴性菌，包括枯草芽孢杆菌（Bacillus subtilis）、单核增生李斯特菌（Listeria monocytogenes）、大肠杆菌（Escherichia coli）、铜绿假单胞菌（Pseudomonas aeruginosa）以及霍乱弧菌（Vibrio cholerae）。在实...
胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种主要由肠道L细胞所产生的激素,属于一种肠促胰岛素(incretin)),促进胰岛素分泌,抑制胰高血糖素分泌,抑制胃动力,使胃排空延迟,通过中枢神经系统抑制食欲。但是GLP-1在血液中半衰期(t1/2)仅数分钟。药物开发在寻找GLP-1类似物,阿斯利康(AstraZeneca),诺和诺德...
Amyloid-β (Aβ) is a naturally occurring peptide known to aggregate and form deposits termed senile plaques in the brains of Alzheimer's Disease (AD) patients. The monomeric Aβ peptide is produced by proteolytic cleavage of a larger precursor protein and is found in both 40- and 42-...
To clarify this association, in this study, we compared SGLT2is users and glucagon-like peptide-1 receptor agonists (GLP-1RAs) users in terms of the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery. A retrospective cohort analysis was conducted using data from...
还有部分低分子量肽可以通过与其他蛋白质或生物大分子相互作用,改变它们的结构和功能,参与蛋白质 - 蛋白质相互作用网络。然而,对于特定的 LMW Peptide(1818202 - 23 - 1),由于缺乏氨基酸序列等详细信息,其具体作用机理尚不明确,需要进一步深入研究。 研究进展:在药物研发领域,低分子量肽因其相对简单的结构和潜在的...
Proteinprotein interactions, as a consequence of advances in molecular techniques with strategies involving the combined use of in silico methods, have enabled the design of thera- peutic peptides to reach an advanced dimension. In particular, with the advantages provided by protein/peptide structural...
Solid-state nuclear magnetic resonance (NMR) spectroscopy was applied to the membrane- bound form of a synthetic peptide representing the 23-residue N-terminal fusion peptide domain of the HIV-I gp41 envelope glycoprotein. Ip solid-state NMR line width measurements of singly ~(13)C carbonyl labe...
Construction of theinterpenetrating polymer network (IPN) in hydrogelshas received increased attention because it not only improves theirmechanical properties but also mimics the extracellular matrix, whichcan be used as cell culturing scaffolds for tissue engineering. Usually,IPN gels are prepared using ...
The present invention relates to a peptide of general formula (I): R1(AA)n-X1-Gly-Glu-Leu-SBr-X2-X3-(AA)P-R2, derived from human HMG-CoA reductase. The present invention also relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in...