Amide Bond (Peptide Bond)doi:10.1002/9780471650126.dob0022.pub2R. LaskowskiT. BeerAmerican Cancer Society
(OtBu)-Phe-Rink Amide resin) was synthesized manually and after Fmoc deprotection of the N-terminal β-Ala residue, a solution of CHX-A″-DTPA•3HCl (1.4 eq.) and DIPEA (9 eq) in dichloromethane (DCM)/dimethylformamide (DMF) (2:1, v/v) was added to the resin-bound peptide ...
The Tasmanian devil faces extinction due to devil facial tumour disease (DFTD), a highly transmittable clonal form of cancer without available treatment. In this study, we report the cell-autonomous antiproliferative and cytotoxic activities exhibited by
In this study, polyarginine was conjugated on the surface of HepG2 cells derived exosomes via an amide bond [56]. The ASOs were either directly inserted into the membrane of the exosomes, or interacted by electrostatic forces with the cationic polyarginine sequences at the surface of the ...
Peptide backbone modifications, involving either α-carbon changes or amide bond replacements, furnish new hybrid structures (pseudopeptides) with often profoundly altered physical and biological properties. Using both direct (ψ-condensation) and indirect (preformed pseudodipeptide) solid phase approaches,...
Structurally, mature AM comprises 52 amino acids containing a disulphide bond between Cys16 and Cys21, and a C-terminal amide, which is formed by peptidylglycine alpha-amidating monooxygenase (PAM). AM belongs to the calcitonin-gene-related peptide (CGRP) superfamily what includes calcitonin (CT)...
Besides the amine vs. amide coordination, the hydrogen bond network around the NiSOD active site is considered to play an important role in preventing sulfur-based ligand oxidation in various studies on non-peptidic model systems21,36,38. Especially, hydrogen bonds to the Ni(II)-ligating sulfur...
The Rink amide MBHA resin (100−200 mesh; 1.2 mmol/g, 1 g) was used as the solid-phase support, and the synthesis was performed on a scale of 20 μmol. The peptides were synthesized by consecutive deprotecting and coupling steps. Coupling step: Fmoc-protected amino acids (4...
It should be appreciated that an internalization peptide may be linked to an active peptide via an amide bond to form a fusion peptide, but they may also be linked via other suitable means, such as chemical bonding. Coupling of two components can be achieved with a coupling agent or a conj...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy