Peptide-Based PROTAC Degrader of CDA1 Suppresses Diabetic Kidney Diseasedoi:10.1681/ASN.2024c6f3wqr4Jiao WuShasha ChengYingying ZhangXiaoyan LiXia ZhouXiaogang LiAmerican Society of NephrologyJournal of the American Society of Nephrology
There is more space for the improvement of the working efficacy of xStAx-VHLL. The VHL peptide ligand inserted in this study consists of natural amino acids, which could be degraded once the PROTAC peptide enters the cell. Non-natural residues substitution instead of original ones, such as r...
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Anticancer peptides (ACPs) perform a promising role in discovering anti-cancer drugs. The growing research on ACPs as therapeutic agent is increasing due to its minimal side effects. However, identifying novel ACPs using wet-lab experiments are generally
(3):944. article pubmed pubmed central cas google scholar wang k, dai x, yu a, feng c, liu k, huang l. peptide-based protac degrader of foxm1 suppresses cancer and decreases glut1 and pd-l1 expression. j exp clin cancer res. 2022;41(1):289. article pubmed pubmed central cas...
103646, 10.1016/j.jprot.2020.103646 View PDFView articleView in ScopusGoogle Scholar Arnold et al., 1980 R.R. Arnold, M. Brewer, J.J. Gauthier Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms Infect Immun, 28 (1980), pp. 893-898 CrossrefView in ...
The elemental composition of peptides results in formation of distinct, equidistantly spaced clusters across the mass range. The property of peptide mass clustering is used to calibrate peptide mass lists, to identify and remove non-peptide peaks and for
Bioorthogonal PROTAC Prodrugs Enabled by On-Target Activation 2023, Journal of the American Chemical Society Identification of a pH-Responsive Peptide-Paclitaxel Conjugate as a Novel Drug with Improved Therapeutic Potential 2023, Journal of Medicinal Chemistry Delivery of RGD-modified liposome as a target...
After this optimization process, the sequence formula was used as a query against the UniProtKB Swiss-Prot and TrEMBL databases. The formula was advanced one position at a time through 18 iterations to represent an entire 18-residue helical wheel span. ScanProsite search results were further limite...
The PGHS-2 sequence maybe cloned into non-essential regions (for example the polyhedrin gene) of the virus and placed under control of an AcNPV promoter (for example the polyhedrin promoter). Successful insertion of the coding sequence will result in inactivation of the polyhedrin gene and ...