aA vector was engineered to express the opioid peptide precursor, human preproenkephalin,the post-translational processing of which yields enkephalin,a ligand that binds opiate receptors in the spinal cord involved in the modulation of pain transmission in the dorsal horn. 传染媒介被设计表达opioid肽...
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for bindin...
we examined whether Ecrg4(71–132) binds to other CTLD-containing receptors (CLRs). None of the CLRs tested bound Ecrg4(71–132) in the cultured-cell-based binding assay (Supplementary Fig.S4). We then addressed whether Ecrg4(71–132) bound to the scavenger receptors consisting of 7 ...
Here, we have determined the structure of the FTZ-F1 ligand-binding domain (LBD)·FTZ peptide complex using x-ray crystallography. Strikingly, the ligand-binding pocket of the FTZ-F1 LBD is completely occupied by helix 6 (H6) of the receptor, whereas the cofactor FTZ binds the co-activator...
A new type of synthetic peptide library for identifying ligand-binding activity. Nat. Cell Biol. 1991, 354, 82–84. [Google Scholar] [CrossRef] [PubMed] Di Natale, C.; De Benedictis, I.; De Benedictis, A.; Marasco, D. Metal–Peptide Complexes as Promising Antibiotics to Fight ...
Structural basis for ligand and heparin binding to neuropilin B domains. Proc. Natl. Acad. Sci. USA 2007, 104, 6152–6157. [Google Scholar] [CrossRef] [Green Version] Soker, S.; Miao, H.Q.; Nomi, M.; Takashima, S.; Klagsbrun, M. VEGF165 mediates formation of complexes containing...
(57) [Abstract] The present invention relates to a blocking peptide capable of binding to a ligand for (EGFR) epidermal growth factor receptor or the erbB-2 receptor. The blocking peptides of the present invention, can be used to detect the presence of a ligand such molecules. Furthermore,...
ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH),1999年成立,总部位于德国不伦瑞克,是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外,ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品,产品线主要包括重组蛋白(细胞因子、生...
Ligand-induced Internalization and Recycling of the Human Neuropeptide Y2 Receptor Is Regulated by Its Carboxyl-terminal Tail Agonist-induced internalization of G protein-coupled receptors plays an important role in signal regulation. The underlying mechanisms of the internalizati... C Walther,S Nagel...
Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides Author links open overlay panelSteven L. Parker a, Michael S. Parker b, Armin Buschauer c, Ambikaipakan Balasubramaniam dShow more Add to Mendeley Share Cite...