aA vector was engineered to express the opioid peptide precursor, human preproenkephalin,the post-translational processing of which yields enkephalin,a ligand that binds opiate receptors in the spinal cord involved in the modulation of pain transmission in the dorsal horn. 传染媒介被设计表达opioid肽...
we examined whether Ecrg4(71–132) binds to other CTLD-containing receptors (CLRs). None of the CLRs tested bound Ecrg4(71–132) in the cultured-cell-based binding assay (Supplementary Fig.S4). We then addressed whether Ecrg4(71–132) bound to the scavenger receptors consisting of 7 ...
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for bindin...
Here, we have determined the structure of the FTZ-F1 ligand-binding domain (LBD)·FTZ peptide complex using x-ray crystallography. Strikingly, the ligand-binding pocket of the FTZ-F1 LBD is completely occupied by helix 6 (H6) of the receptor, whereas the cofactor FTZ binds the co-activator...
A new type of synthetic peptide library for identifying ligand-binding activity. Nat. Cell Biol. 1991, 354, 82–84. [Google Scholar] [CrossRef] [PubMed] Di Natale, C.; De Benedictis, I.; De Benedictis, A.; Marasco, D. Metal–Peptide Complexes as Promising Antibiotics to Fight ...
Structural basis for ligand and heparin binding to neuropilin B domains. Proc. Natl. Acad. Sci. USA 2007, 104, 6152–6157. [Google Scholar] [CrossRef] [Green Version] Soker, S.; Miao, H.Q.; Nomi, M.; Takashima, S.; Klagsbrun, M. VEGF165 mediates formation of complexes containing...
(57) [Abstract] The present invention relates to a blocking peptide capable of binding to a ligand for (EGFR) epidermal growth factor receptor or the erbB-2 receptor. The blocking peptides of the present invention, can be used to detect the presence of a ligand such molecules. Furthermore,...
ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH),1999年成立,总部位于德国不伦瑞克,是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外,ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品,产品线主要包括重组蛋白(细胞因子、生...
Ligand-induced Internalization and Recycling of the Human Neuropeptide Y2 Receptor Is Regulated by Its Carboxyl-terminal Tail Agonist-induced internalization of G protein-coupled receptors plays an important role in signal regulation. The underlying mechanisms of the internalizati... C Walther,S Nagel...
Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides Author links open overlay panelSteven L. Parker a, Michael S. Parker b, Armin Buschauer c, Ambikaipakan Balasubramaniam dShow more Add to Mendeley Share Cite...