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elucidated the NMR structure of a β-hairpin formed by Aβ40 using an affibody to sequester and stabilize the β-hairpin (Figure 2a) [42]. In this β-hairpin, residues 17–23 and 30–36 of Aβ hydrogen bond to form an antiparallel β-sheet, whereas the intervening residues, 24–29, ...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination...
Amphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide while focusing on structural flexibility. We designed conformationally...
(ncAAs) have been incorporated genetically into Nisin A113which led to formation of a novel ring A thioether bond for one of the mutants leading to overall property enhancement of bacteriocin. In another recent research, lapidated variant of nisin was developed by insertion of ncAAs in nisin ...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination...
In the deeper site the <SPAN style="FONT-STYLE: italic">N</SPAN>-formyl group and methionine side chain were situated in positions comparable to those in the <SPAN style="FONT-STYLE: italic">N</SPAN>-formyl tripeptides, but the peptide bond between methionine and tryptophan was in the ...
Further modifications led to the discovery of dialkyl cationic amphiphile peptidomimetics bearing two identical length lipophilic alkyl chains and one non-peptidic amide bond, still keeping the previously established hydrophobicity–cationicity ratio. The most potent dialkyl cationic amphiphile 4g was not ...
It also alters the hydrogen-bond pattern of the peptide through reducing the number of hydrogen bond donors. Other backbone modifications, such as the use of foldamers, β-peptides and peptoids can additionally infer both proteolytic and metabolic stability [69,70]. Cyclic peptides have ...
Our findings show that the three groups share several similarities in general, but they display distinctive features upon examination in terms of their amino acid compositions and frequencies, and various physico-chemical properties. Thus, analysis or prediction of their sequences should be separated ...