The peptide PT-141 has been shown to have a substantial effect on libido, generating sexual arousal in both men and women.
Peptide drug development entered a new era with the advent of the 21st century, since when advances in structural biology, recombinant biologics, and new synthetic and analytic technologies have significantly accelerated the process. A sophisticated system of peptide drug development has been established,...
Andersson,B.,Leksell,L. G., andRundgren,M., 1975, Duration of central action of angiotensin II by its interaction with CSF Na+,Acta Physiol. Scand.93:472–476. PubMedGoogle Scholar Anderson,C. O.,Zarrow,M. X.,Fuller,G. B., andDenenberg,V. H., 1971, Pituitary involvement in matern...
Schematic overview of peptide effects on different epigenetic mechanisms. (a) Short peptides inhibit DNA methylation by blocking DNA methyltransferase binding or initiation of strand separation. (b) BCM7, GM7, and Aβ suppress DNA methylation by inhibiting cysteine uptake and lowering the SAM/SAH r...
pp 141–180 Cite this chapter Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function Isin Cakir & Eduardo A. Nillni 899 Accesses Abstract The hypothalamus is an important center for coordinating mammalian physiology and maintenance of homeostasis. Accordingly, the hypothalamus ...
This review is an attempt to illustrate the diversity of peptides reported for a potential or an established use in cancer therapy. With 612 references, this work aims at covering the patents and publications up to year 2000 with many inroads in years 2001–2002. The peptides are classed acc...
analog boosts sexual desire in female rats [Proc.Natl.Acad.Sci.USA,published online June 28,http://dx.doi.org/10.1073/pnas.0400491101].Researchers first noticed that PT-141,a cyclic heptapeptide that mimics the action of alpha-melanocyte-stimulating hormone (alpha-MSH),causes erections in men....
Maeno M, Nakamura Y, Mennear JH, Bernard BK (2005) Studies of the toxicological potential of tripeptides (L-Valyl-L-prolyl-L-proline and L-Isoleucyl-L-prolyl-L-proline): III. Single-and/or repeated-dose toxicity of tripeptides containing Lactobacillus helveticus-fermented milk powder and ...
Claire G,Maurizot J.C.,Durand M.Conformational variability of the synthetic peptide 129-141 of the mouse prion protein. Journal of Biomolecular Structure and Dynamics . 2000Prevost M, Jacquemotte F, Oberg KA, Staelens D, Devreese B, Van Beeumen J (2000) Conformational variability of the ...
Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte antigen (HLA) peptide ligands are promising leads to invoke targeted anti-