An example of an enzyme with a relatively narrow mission is folylpoly-γ-glutamate carboxypeptidase, which converts food folate into the absorbable free form. The many people who have a slightly less active form absorb food folate less well and are more likely to suffer detrimental consequences ...
MicroRNAs (miRNAs) are single stranded, 18–23 nucleotide-long, RNA molecules, which can be poly- morphic and can affect maturation and function of the miRNA, possibly resulting in disease. For example, the pri-miR-15a/miR-16 C/T polymorphism is associated with familial chronic lymphocytic ...
Pepsinogen Cor progastricsin (PGC) is an APenzymepresent ingastric secretionandseminal plasma protein. It is azymogenhaving 374 residues, consisting of 331 residues gastracin moiety and 43 residues long activation segment, which is activated in acidic condition (Foltmann, 1988). The enzyme is ...
Pepsin hydrolyzes N- and C-terminally blocked syntheticdipeptideslike Glu↓Tyr or Phe↓Phe but with poor efficiency. For example, thekcat/Kmof Z-Phe Phe-OP4P (OP4P: 4-pyridinium alkoxy) is only 0.7s−1mM−1. Placing additional Gly or Ala residues on either side of the Phe-Phe sequ...