The mechanism of action of pentamidine is not known. The drug concentrates in trypanosomes via an energy-dependent, high affinity uptake system, which operates more rapidly in drug sensitive strains. Inside the cell, pentamidine interacts with nucleic acids thus affecting DNA biosynthesis[2]. It ha...
Bornstein et al., “An Evaluation of the Mechanism of Action of Pentamidine Isethionate,” Journal of Surgical Oncology, 2:393-398, 1970. ;, 2:393-398, 1970.Bornstein RS, Yarbro JW (1970) An evaluation of the mechanism of action of pentamidine isethionate. J Surg Oncol 2: 392–398...
Pentamidine, recently released for clinical use, is effective in therapy for the hemolymphatic stage of Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia. The mechanism of action is unclear and may differ for different organisms. Trypanosomes actively transport ...
Mechanism of Action Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. However, the mode of action is not fully understood. Activity in vitro and in vivo Pentamindine isethionate, an aromatic diami...
The Properties of Linezolid, Rifampicin, and Vancomycin, as Well as the Mechanism of Action of Pentamidine, Determine Their Synergy against Gram-Negative B... Combining pentamidine with Gram-positive-targeting antibiotics has been proven to be a promising strategy for treating infections from Gram-...
Pentamidine isethionate is primarily used in the treatment of various protozoal infections, including Pneumocystis pneumonia and leishmaniasis. Its mechanism of action involves inhibiting the replication of the protozoa by interfering with their DNA and RNA synthesis. Storage Conditions Store in a cool, ...
The mechanism of action of this product is not clear enough. It may interfere with nucleotide biosynthesis and DNA replication, as well as the conversion of folate. It has a direct killing effect on Leishmania. It is the first choice for the treatment of cancer and AIDS complicated with ...
Effects of pentamidine isethionate on Saccharomyces cerevisiae We used Saccharomyces cerevisiae as a model system in which to examine the mechanism of action of the anti-Pneumocystis drug pentamidine. Pentamidine at lo... G Ludewig,JM Williams,Y Li,... - 《Antimicrobial Agents & Chemotherapy》 被...
To determine the mechanism of pentamidine, fluorescent labeling assays were used to measure membrane permeability, membrane potential, efflux pump activity, and reactive oxygen species (ROS); the LPS neutralization assay was used to evaluate the target site; and quantitative PCR was...
As far as we know, this is the first report that shows that pentamidine induces PCD in unicellular eukaryotes. In addition, we shed further light on the molecular mechanism of action of pentamidine, demonstrating that this drug modifies the structure of both DNA and the ubiquitin protein.by ...