3.7) mimics the structure of the major allergenic determinant [52]. Penicilloyl polylysine was commercialized as a skin test reagent to detect the resulting immunoglobulin E [53]. The amide sidechain influences the cross-reactivity [52]. Generally, the cephalosporin, carbapenem, and monobactamβ...
most obligate anaerobes; inactive vs. most aerobic bacteria or facultative anaerobes. Table 15-3. Antimicrobial Therapy Used in Exotic Animals According to Site of Infection.a,b Site of InfectionAntimicrobial Agent Bacteremia, septicemia Aerobic bacteria Aminoglycoside with a penicillin or cephalosporin...
Cooper RD (1993) The enzymes involved in biosynthesis of peni- cillin and cephalosporin; their structure and function. Bioorg. Med. Chem. 1: 1-17R.D.G. Cooper, The enzyme involved in biosynthesis of penicillin and cephalosporin; their structure and function, Bioorg. Med. Chem. (1993) 11-...
a history of reaction to penicillin indicates a more than 50% risk of an allergic reaction and penicillin should be avoided, or if penicillin is mandatory, desensitization should be considered. Cross-reactivity exists between cephalosporins and penicillins due to the commonβ-lactam ring structure. ...
In certain severe infections (e.g. sepsis) when the causative organism is unknown orP. aeruginosais suspected, some clinicians recommend that concomitant therapy with an aminoglycoside or third-generationcephalosporinbe used pending results ofin vitrosusceptibility tests. Synergistic effects between extended...
In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci. Antimicrob. Agents Chemother. 2001, 45, 825–836. [CrossRef] [PubMed] 62. Henry, X.; Amoroso, A.; Coyette, J.; Joris, B. Interaction of ...