Benzathine penicillin G has been recommended by the Center for Disease Control and the American Academy of Pediatrics for treatment of congenital syphilis in spite of the lack of published data concerning clinical pharmacology and efficacy of the drug in this disease. Five newborn infants received a...
The use of long-acting penicillin in the prophylaxis of congenital syphilis.Syphilis, CongenitalPenicillinsdoi:10.1111/j.1471-0528.1959.tb01141.xG. M. ThomsonJohn Wiley & Sons, Ltd.J Obstet Gynaecol Br Emp
There are no proven alternatives to penicillin G for the treatment of congenital syphilis in infants and children with known or suspected penicillin hypersensitivity and no proven alternatives to penicillin G for the treatment of any stage of syphilis in pregnant women with penicillin hypersensitivity; ...
000U/kg intramuscularly as a single dose. If any part of the evaluation for congenital syphilis is abnormal,CSF examinationis not interpretable, CSF examination was not performed, or follow-up is uncertain, procaine penicillin G is recommended. A single dose of ceftriaxone is not considered ...
A Herxheimer reaction occurred in a 1-month-old breastfed infant with congenital syphilis 6 hours after a 2.4 million-unit IM dose of benzathine penicillin G was administered to the mother; the infant had also received 10 units of penicillin G at about the time of the maternal dose. The ...
The FDA approved the importation of an antibiotic that treats syphilis amid a penicillin shortage in the U.S. The shortage is partially due to an increase in syphilis diagnoses, including congenital syphilis. The FDA said this week that it is working with a French pharmaceutical company to tempo...
Handler Congenital syphilis in the past: Slaves at Newton Plantation, Barbados, West Indies, American Journal of Physical Anthropology 89, no.22 (Oct 1992): 145–158.https://doi.org/10.1002/ajpa.1330890203György Pàlfi, Olivier Dutour, Marc Borreani, Jean-Pierre Brun, Jacques Berato Pre-...
Syphilis - Aqueous penicillin G may be used in the treatment of acquired and congenital syphilis, but because of the necessity of frequent dosage, hospitalization is recommended. Dosage and duration of therapy will be determined by age of patient and stage of the disease. ...
Congenital syphilis Infants under 2 years should receive aqueous crystalline penicillin 100 000–150 000 U/kg per day, administered intravenously as 50 000 U/kg (30–60 mg) per dose, every 12 h for the first 7 days of life, and every 8 h thereafter for a total of 10 days, as recomme...
Because central nervous system involvement in congenital syphilis is difficult to exclude with certainty, benzathine penicillin G should not be used for therapy for this disease unless new diagnostic modalities to rule out neurosyphilis are developed.164 Its use for asymptomatic infants with normal findi...