CDC has a Clinical Reminder regarding how to evaluate supply and recommendations for use of other products such as doxycycline when possible. This document is aimed to help public health entities ensure they have supply of penicillin G benzathine for patients with syphilis. This note can be found...
In cases of penicillin allergy or parenteral treatment refused, the treatment of choice is doxycycline 200 mg twice per day for 28 days. In pregnancy, the treatment of choice is benzathine penicillin 2.4 million units intramuscularly as a single dose or procaine penicillin 600 000–1.2 million ...
Since an alternative drug can usually be found, a penicillin is best avoided if there is suspicion of allergy, although the condition is undoubtedly overdiagnosed and may be transient (see below). When the history of allergy is not clear cut and it is necessary to prescribe a penicillin, ...
any type of allergy; asthma or breathing problems; a stomach or intestinal disorder; heart disease; or kidney disease. If you have stomach problems or are sick with severe vomiting or diarrhea, your medication may not be as effective.
Therefore in serious infections, the benefit of doxycycline may outweigh its potential harm in pregnant women. There are few drug interactions associated with tetracyclines, although they can interfere with warfarin levels. Tetracyclines may reduce the efficacy of oral contraceptives, and additional forms...