来源:肿瘤资讯 PEMBRO-RT研究(ABS:9023) 时间:当地时间6月3日, 11:30 am-12:45 am 地点: Arie Crown Theater 背景 大剂量的放射治疗可以引起肿瘤抗原的释放,而肿瘤抗原的释放可以增加抗原呈递和T细胞的浸润,因此,大剂量放疗治疗一定...
However, because RT induces immune-mediated cell death that can generate a rich supply of tumor antigens and trigger anti-tumor immunity, the addition of pembro to RT can generate robust anti-tumor immune responses as demonstrated in metastatic TNBC (McArthur ASCO 2018). If administered in the...
1 pt had grade 5 toxicity (aortic fistula), from re-RT. Conclusions: In the first prospective trial of PBT re-RT + consolidation pembro, treatment proved feasible and PFS was acceptable though the capacity to administer pembro was limited. This approach may be considered in selected patients ...
271TiPPreoperative pembrolizumab (Pembro) with radiation therapy (RT) in patients with operable triple-negative breast cancer (TNBC)doi:10.1093/annonc/mdy270.265McArthur, H LBasho, RShiao, SPark, DDang, CKarlan, SKnott, SMita, MDilauro Abaya, C...
McArthur HL, Barker CA, Gucalp A et al. A single-arm, phase II study assessing the efficacy of pembrolizumab (pembro) plus ra- diotherapy (RT) in metastatic triple negative breast cancer (mTNBC). 2018 ASCO-SITC Clinical Immuno-Oncology Symposium 2017....
58% of pts in the control arm had crossed over on-study to pembro monotherapy. Pembro + chemo improved OS, PFS, ORR, and DOR vs placebo + chemo (Table). Grade 3 5 AEs occurred in 89% and 87% of pts in the pembro ...