PBAE: 聚β氨基酯(PBAE)是由β-氨基酸或相关化合物聚合而成的高分子,具有较强的生物可降解性和较好的生物相容性。PBAE在药物递送中作为载体材料,具有良好的稳定性和较低的细胞毒性。 C14: 十四烷基链(C14)是长烷基链,在结构中提供疏水性,从而增加聚合物的疏水性和与生物膜的亲和力。它常用于改善聚合物的自组装...
Polyethylene glycol (PEG)-b-poly(尾-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as...
PH敏感化学键MPEG-PBAE,PHVB-g-PEG产品 西安瑞禧供应环境响应性共聚物产品(二硫键、腙键、柠糠酸) 在2种不同的聚合物之间用二硫键或腙键或柠糠酸连接,使其具备氧化还原敏感型和PH响应型,不同的聚合物有PEG、PEI、Hyaluronate、Dextran、Chitosan、PLGA、PCL、PLA、P2VP、PAA、PMMA等等。我们还可以在这些聚合...
12,19,20 However, the combination of PBAE-PEG (or PBAE) and SORT lipids (4A3-SC8/DOPE/cholesterol/DOTAP; hereafter, LNP) to create PBAE-PEG/LNP or PBAE/LNP has not been extensively explored. In the present study, we synthesized two distinct types of PBAEs, PBAE-PEG and PBAE, and ...
超支化PBAE(聚β-氨基酯)聚合物纳米粒是一种具有高度支化结构的生物降解性材料,通过其氨基与带负电的分子(如mRNA)形成稳定的静电复合物,保护分子免受降解,同时提供高效的细胞摄取和靶向递送能力。mRNA是指信使RNA,它携带遗传信息用于指导蛋白质的合成,在CRISPR-Cas13a系统中,mRNA编码Cas13a酶,Cas13a是一种能够...
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Polyethylene glycol (PEG)-b-poly(尾-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as...
Polyethylene glycol (PEG)-b-poly(尾-amino ester) (PBAE) co-polymers (PEG- PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such ...
Polyethylene glycol (PEG)-b-poly(尾-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as...
Polyethylene glycol (PEG)-b-poly(尾-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as...