活化的T细胞和树突状细胞能够分泌IL-10来发挥抗炎症作用,但是在高浓度下,IL-10及PEG-IL-10则可以启动CD8+T细胞的增殖和细胞毒。实验性肿瘤中IL-10的升高会引起T细胞介导的肿瘤排斥,动物模型中,通过PEG-IL-10(Pegilodecali)使得血清IL-10浓度持续升高,增强了肿瘤特异性CD8+ T细胞的细胞毒和扩增,最终引起肿瘤的...
A method of producing a mixture of mono- and di-PEGylated IL-10 in which a PEG molecule is covalently attached to an amino acid residue of a subunit of IL-10 comprises: reacting IL-10 with an activated PEG-linker, such as PEG-propylaldehyde or succinimidylcarbonate-PEG, in the presence ...
Furthermore, we show that IL-10's increase of Kupffer cell cholesterol phagocytosis is concomitant with decreases in liver cholesterol and triglycerides. This leads to the reversal of early periportal liver fibrosis and facilitates the restoration of liver health. These data recommend PEG-rIL-10 for...
上海玉博生物科技有限公司做为cisbio代理商之产品62HIL10PEG-Human IL10 kit的产品销售公司,专业经营原装进口抗体(单克隆、多克隆)、重组蛋白、检测试剂盒、标准品、细胞因子、胎牛血清、细胞培养类等生物试剂以及耗材。 ATCC sigma anatrace caroteNature NIBSC medkoo thermo life CIL macrocyclics invitrogen ...
PEG-10 OLEATE CAS号 9004-96-0 结构式图片 别名 PEG-10 OLEATE [INCI];AEC PEG-10 OLEATE;NIKKOL MYO-10;POLYETHYLENE GLYCOL 500 MONOOLEATE;POLYOXYETHYLENE (10) MONOOLEATE 扩展信息 VIP试用医疗器械查询APP下载客服中心常见问题数据可视化数据分析挖掘系统网站地图业务介绍友情链接 400-678-077...
PEG-10 STIGMASTANOL 结构式图片 别名 STIGMASTANOL PEG-10 扩展信息 VIP试用医疗器械查询APP下载客服中心常见问题数据可视化数据分析挖掘系统网站地图业务介绍友情链接 400-678-0778 投诉热线: (023) 6262 8397 邮箱: tousu@yaozh.com QQ: 236960938 友情链接: 药物在线 药品注册查询 临床试验查询...
Finally, we show that the recruitment and re-education of mononuclear phagocytes by combined delivery IL-10 and AT-RvD1 localizes immune suppressive subsets to the hydrogel, including CD206 macrophages (M2a/c) and IL-10 expressing dendritic cells in the context of chronic inflammation following ...
-linker such that the IL-10 to PEG-linker ratio is 1:1 to 1:7.7, in the presence of 0.75 mM to 35 mM of a reducing agent, at a pH of about 5.0 to 7.4 and a temperature of 5掳C to 30掳C, for 12-15 hours; and b) purifying the mixture of mono- and di-pegylated IL-10....
Mono- and di-PEG IL-10 production; and usesProvided are methods of producing mono- and di-pegylated IL-10.Blaisdell, Steven JCutler, Collette MPaporello, Brittany CAmbrogelly, Alexandre
化学名 METHOXY PEG-10 CAS号 9004-74-4 结构式图片 别名 METHOXY PEG-10 [INCI];POLYETHYLENE GLYCOL 500 MONOMETHYL ETHER;POLYOXYETHYLENE (10) MONOMETHYL ETHER;CARBOWAX MPEG 550;PEG-10 METHYL ETHER;POLYETHYLENE GLYCOL MONOMETHYL ETHER (MW 470) 中文名 聚乙二醇单甲醚 扩展信息 VIP...