(102 mg). The identity was confirmed by matrix-assisted laser desorption/ionization–time of flight mass spectrometry where a series of peaks separated by 44 a.m.u. (the repeat unit mass of PEG) were observed between approximately 3,900 and 4,300 m/z. The three strongest peaks at...
By taking μpc and μpl,0 as the specific chemical potentials (i.e., the Gibbs free energy per unit mass) of the polymer in the pure crystalline and liquid states, it follows from the definition of the (specific) Gibbs free energy of crystallization Δgcrys. that (10)Δgcrys.=μpc...
Bradley et al., “Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat,” J. Mol. Biol., 2002, 324: 373-386. Coiffier B. et al., Efficacy and Safety of Rasburicase (recombinant urate oxidase) for...
Anti-PEG Fabs bind to PEG as symmetrical dimer complex Fig. 1: Anti-PEG Fabs form dimer complex with single PEG chain antigen. Overall view of the complex in the asymmetric unit with polyethylene glycol (PEG) polymer antigen (carbon, cyan; oxygen, red) bound between two APA Fabs with colo...
For both PEG and TPGS, PEG was selected as a repeat monomer for the formation of a decamer. The succinate linker was employed when introducing the α-tocopherol head into the TPGS polymer. The final polymers were cross-linked and allowed to form amorphous cells. For the docking operation, ...