Seizures not responding to the first- and second-lines drugs (initial doses of benzodiazepines, IV phenytoin/fosphenytoin, Keppra, valproic acid, phenobarbital) should be considered refractory status epilepticus (RSE). Prolonged refractory status epilepticus (seizures persisting beyond 24 h) needs further...
Clinical features of calcipenic rickets. (a) 18-month-old girl presenting with genu vara, and widening of the growth plates and metaphyseal fraying on X-rays, caused by nutritional rickets. (b, c) Two infants with widening of the wrist and rachitic rosary, respectively, due to nutritional r...
In addition, the incidence of medical frailty, as defined by five domains (walking limitations, low energy, exhaustion, low lean mass, and weakness) is significantly higher in survivors of pediatric cancer than in sibling controls [81]. Structured exercise demonstrates improvement in mortality, ...
The ASO-RNA binding energy should be ∆Go37≥ −8 kcal/mol to provide a more effective response [46,52]. The above-mentioned oligonucleotide properties can be measured using the online software Oligo Calc (http://biotools.nubic.northwestern.edu/OligoCalc.html (accessed on 16 September 2022...
(BCKAD) enzyme complex leads to the metabolic disease MSUD. The enzymes, being essential to life, are proteins in their most basic form. Proteins are essential for human survival and development and can also be broken down and used as a source of quick energy. Amino acids come in 20 ...