This review will address the "status of the art" related to the potential of natural compounds that are undergoing investigation in combination with standard therapeutic protocols in preclinical and clinical studies and their importance for pediatric cancer treatment. The early studies of drug discovery...
Cancer Epidemiology Cancer Immunology Cancer Immunotherapy Cancer Registries Cancer Screening Cancer Survivorship Cancer Vaccines CAR-T Therapy Chemotherapy Protocols Child Life Services Childhood Lymphoma Clinical Ethics Clinical Trials Digital Pathology
Research can explore innovative treatment protocols, the impact of technology (e.g., wearables, telehealth), and the integration of multidisciplinary care teams to improve long-term outcomes. Infectious Diseases and Vaccination: Explore the epidemiology, prevention, and treatment of infectious diseases ...
Many treatment protocols advanced LBL therapy over the past 15 years; highlights of these studies are briefly summarized: The German Berlin–Frankfurt–Munster (BFM)-90 regimen administered CRT to all advanced patients, independent of CNS involvement. Although EFS was 90% in stage III–IV patients,...
Classifying the intensity of pediatric cancer treatment protocols: The intensity of treatment rating scale 2.0 (ITR-2). Pediatr Blood Cancer. 2007;48(7):673–7. Article Google Scholar Glasgow RE, Ory MG, Klesges LM, Cifuentes M, Fernald DH, Green LA. Practical and relevant self-report ...
This time her cancer, which currently has a poor prognosis and no established cure in cases of relapse, was resistant to three different chemotherapy protocols. Doctors at Spectrum Health’s Helen DeVos Children’s Hospital in Grand Rapids, Michigan, told Maddie’...
Overall, 30%–35% of pediatric patients will receive radiotherapy during first-line therapy or for recurrent disease during their cancer treatment [2]. Despite significant improvements in overall survival over time, approximately 20%–25% of all children diagnosed with cancer will die and at least...
Through the utilization of genomic and transcriptomic profiling, these protocols aim to refine diagnosis and prognosis, detect germline cancer predis- position, identify targeted therapeutic options, and/or to determine eligibility for clinical trials in patients with rare, treatment-refractory, relapsed, ...
A phase I study on patients with advanced solid tumors has assessed the dose and treatments protocols showing that although RG7112 was generally well toler- ated, the more effective schedule in terms of adequate P53 tumor activation was anyhow associated to increased hematological toxicities [95]. ...
Many patients after pediatric cancer suffer from long-term cognitive difficulties. This study investigates the development of cognitive and psychosocial functions between diagnosis and one year after cancer treatment and reveals insight into the association between cognitive and psychosocial development and var...