The cell adhesion and signaling molecule, PECAM-1, is expressed in many hematopoietic and endothelial cell malignancies, and has previously been shown to suppress mitochondrial-dependent, Bax-mediated apoptosis. The ability of PECAM-1 to influence tumor cell survival following exposure to ...
CD31/PECAM-1, or platelet endothelial cell adhesion molecule 1, is a 130-kDa glycoprotein expressed on vascular and hematopoietic cells. Depending on the cell type, CD31/PECAM-1 expression can be largely localized to cell junctions, playing a role in cell adhesion. Aside from its r...
名称 CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) 描述 Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation...
The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes Blood, 82 (1993), pp. 2649-2663 View PDFView articleView in ScopusGoogle Scholar 32 H.M. DeLisser, H.C. Yan, P.J. Newman, W.A. Muller, ...
PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors Blood (2004) R. Bulla et al. VE-cadherin is a critical molecule for trophoblast-endothelial cell interaction in decidual spiral arteries Exp Cell Res (2005) D.G. Tang et al...
PECAM-1 (CD31) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing surface glycoprotein expressed on various hematopoietic cells as well as on endothelial cells. PECAM-1 has been shown to play roles in regulation of adhesion, migration and apoptosis. The BCR/ABL fusion tyrosine ...
Platelet endothelial cell adhesion molecule (PECAM-1) is a type I transmembrane glycoprotein constitutively expressed on the surfaces of endothelial cells and the majority of hematopoietic cells. The goal of this dissertation was to determine whether the inhibitory functions of PECAM-1 play a role in...
The choice between survival or apoptosis, which is the result of such different integrated environmental signals, is crucial for the maintainance of bone marrow reservoir of hematopoietic precursors (HPC). CD34 + HPC can receive multiple survival signals during homing and maturation, due to different...
This may be due to compensatory mechanisms that are only activated in the absence of LAIR-1 and PECAM-1 and deletion of both receptors in other hematopoietic and vascular lineages that contribute to thrombosis. 2. Methods 2.1. Animals LAIR-1/PECAM-1 double-deficient mice were generated by ...
PECAM-1 (CD31/EndoCAM) is an adhesion molecule in the immunoglobulin supergene family that is expressed on endothelial cells, platelets, and some hematopoietic lineage cells. In this paper, using several polyclonal and monoclonal antibodies against PECAM-1, we identified PECAM-1 molecules on human,...