Compared to normal breast samples, PDL1 expression was upregulated in 20% of clinical samples and 38% of basal tumors. High expression was associated with poor-prognosis features (large tumor size, high grade, ER-negative, PR-negative, ERBB2-positive status, high proliferation, ...
Furthermore, PD-1 expression on CD4+ and CD8+ T cells from gastric cancer tissue was significantly higher than that from normal gastric mucosa and PBMC. PD-1 positive CD4+ and CD8+ T cells produced significantly less IFN-gamma than PD-1 negative CD4+ and CD8+ T cells. CONCLUSIONS:Up...
ThepositiveratesofPD1andPDL1inthecancertissues[79.57%(74/93)and79.57%(74/93)]wasmuchhigherthanthethoseoftheadjacentnormalbreasttissues[48.39%(45/93)and22.58%(21/93)](allP<0.05).Inthecancertissues,theexpressionofPD1wasrelatedtothehistologicalgradesandthelymphnodesmetastasis(P<0.05),butnotrelatedto...
内容提示: 肿瘤代谢与营养电子杂志2021年6月9日第8卷第3期 Electron J Metab Nutr Cancer, Jun. 9, 2021, Vol. 8, No. 3·综述·外周血PD⁃1/PD⁃L1在乳腺癌中的研究进展1 袁可玉, 2 宋清坤, 1 吕淑贞, 1 李艳萍( 1 首都医科大学附属北京世纪坛医院乳腺外科,北京 100038; 2 首都医科大学附属...
乳腺癌组织PD1、PDL1表达变化及其与患者临床病理参数和预后的关系
3c). In addition, positive expression of LDHA was also correlated with worse OS and DFS in TNBC tissues (P < 0.01 for both OS and DFS; Fig. 3d). Expression of PDL1 and LDHA is correlated and indicates a poor outcome in breast cancer To further confirm that LDHA is also a target ...
Establishment and characterization of novel highly aggressive HER2positive and triplenegative breast cancer cell lines. Breast cancer cell lines are widely used as aninvitrosystem with which to study the mechanisms underlying biological and chemotherapeutic resistance. In th... S Thongchot,P Jamjuntra...
In this paper, we report the specificity of RK-10 in binding PD-L1 in cells, patient blood samples, and tissues. We have demonstrated that RK-10 binds to PD-L1 positive tumor cells -breast, retinoblastoma, and lung cancer cell lines using flow cytometry. Flow cytometry using RK-10 was ...
采用肿瘤细胞阳性比例分数(tumor cell proportion score,TPS)及联合阳性分数(combined positive score,CPS)指标分析免疫组织化学染色结果评价肿瘤组织的PD-L1表达情况。结果:68Ga-DOTA-PDL1P的标记率及放射化学纯度均大于99%,并在磷酸...
Positive concordance for cfRNA PDL1+ and IHC PDL1+ was 10.2% (6/59). Negative concordance for cfRNA PDL1 - and... S Kato,N Khalid,R Jimenez,... - 《Journal of Clinical Oncology》 被引量: 0发表: 2019年 A new synthesis of tetrathiooxalate and its conversion to C3S5... and C...