该研究认为该特异性抗体通过调节电压依赖性 L 型 Ca2+通道,增加Ca2+内流,诱导心肌结构重构及功能障碍,从而推测cTnI自身抗体的产生是 PDCDl-/-小鼠出现自身免疫性心肌病的重要机制。国内也有研究发现PDCD-1基因rs2227982 位点基因频率在中国汉族人群的DCM患者中明显升高[19]。上述研究表明,PD-1可能通过抑制T细胞的活...
人酸脱羧酶(PDC)ELISA试剂盒 植物赤霉素合成酶(GAS)ELISA试剂盒 小鼠紧密连接蛋白5(Occludin 5)elisa试剂盒 人降钙素(CT)ELISA试剂盒 人C-型凝集素域家族2成员ACLEC2A试剂盒(Member A CLEC2)ELISA试剂盒 公司简介 上海研玘生物技术有限公司是一家专业从事"产品研发、市场销售、技术服务”为一体的高科技生物...
PDL1-TGFβ双抗是个啥? 某司的双抗药物最近上1期临床,其靶点据业界分析是PDL1-TGFβ,这个靶点目前只有德国默克在做,代码M7824,已经进入2期临床,并且在ASCO会议上披露了多个瘤种的1期临床数据。 大多双特异抗体是将Y型单抗两个可变区分别靶向两个不同的靶点,这个双抗不一样,M7824是把TGFβ抗体蛋白作用区(2...
Reaction of the N,N,O-terdentate ligands 6-(2-hydroxyphenyl)-2,2′-bipyridine (HL 1 ) and 2-(2-hydroxyphenyl)-1,10-phenanthroline (HL 2 ) with Na 2 PdCl 4 ·3H 2 O afforded the complexes [PdL 1 Cl] and [PdL 2 Cl]; the crystal structure of [PdL 1 Cl]·(CH 2 Cl 2 )...
Reaction of the N,N,O-terdentate ligands 6-(2-hydroxyphenyl)-2,2′-bipyridine (HL 1 ) and 2-(2-hydroxyphenyl)-1,10-phenanthroline (HL 2 ) with Na 2 PdCl 4 ·3H 2 O afforded the complexes [PdL 1 Cl] and [PdL 2 Cl]; the crystal structure of [PdL 1 Cl]·(CH 2 Cl 2 )...
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