PDH 通常指丙酮酸脱氢酶复合体(Pyruvate Dehydrogenase Complex)。 丙酮酸脱氢酶复合体是一种关键的酶复合体,在细胞的能量代谢过程中发挥着至关重要的作用。它主要负责将丙酮酸转化为乙酰辅酶 A,这是细胞呼吸链中的关键步骤,对产生能量极为重要。 PDH 不仅参与糖酵解后的丙酮酸代谢,还与脂肪酸氧化和氨基酸代谢有关...
相比之下，TCA循环新陈代谢如何被重新编程以帮助肿瘤细胞逃避免疫破坏尚不清楚。PDHE1αPs327促进肿瘤免疫逃逸的机制（图片源自Nature Metabolism ）PDH complex catalysers是线粒体丙酮酸脱羧化的限速步骤，将丙酮酸转化为乙酰辅酶A(CoA)，从而将TCA循环与糖酵解以及脂肪和氨基酸代谢联系起来。PDH复合体由PDH(E1)、二...
PDH是一个多领域术语,具体含义需结合上下文判断。其常见解释包括生物学中的丙酮酸脱氢酶复合体、通信领域的准同步数字系列、项目管理的专业发展学时,以及化工行业的丙烷脱氢工艺。以下从四个主要应用场景展开说明: 一、生物学中的关键酶复合体 PDH(Pyruvate Dehydrogenase Complex)是细胞能量...
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochon- drial matrix enzyme complex that functions as the primary link between gly- colysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversibleconversion of pyruvate into acetyl-CoA. The E1 enzyme of the PDH ...
此外,PDH还指丙酮酸脱氢酶复合体(Pyruvate Dehydrogenase Complex),这是一种在细胞能量代谢中发挥关键作用的酶复合体。 ADH: 在医学领域,ADH代表抗利尿激素(Antidiuretic Hormone),也称为尿崩症激素或vasopressin。它是由垂体腺后叶分泌的一种激素,主要作用是调节体液平衡和浓缩尿液。 请注意,由于PDH和ADH在不同领域有...
The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit ...
The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit ...
Studies on intact rats as well as on perfused rat liver and rat heart indicate that the PDH-complex underlies reversible interconversion by phosphorylation and dephosphorylation, in vivo. With the exception of the brain the proportion of the a and b-form
丙酮酸脱氢酶复合物缺陷(pyruvate dehydro— genase complex,PDHc)是一种罕见的遗传病,是最常见的线粒体呼吸链能量代谢障碍性疾病之一,导致原发性乳酸酸中毒和Leigh综合征。 病因与发病机制: 丙酮酸脱氢酶复合物是连接糖酵解和三羧酸循环的枢纽,催化丙酮酸不可逆的转化为乙酰辅酶A。丙酮酸脱氢酶复合物位于线粒体...
see MIM 300502. The mammalian PDH complex differs from that in E. coli and from the other mammalian alpha-keto acid dehydrogenases by the presence of a 53-kD protein called protein X. Component X binds to the E3 (MIM 238331) component of the PDH complex (Robinson et al., 1990 [PubMed...